PRDM4 Protein

Catalog No. ABIN7939442

This Recombinant PRDM4 protein is produced in Baculovirus infected Insect Cells.

Quick Overview for PRDM4 Protein (ABIN7939442)

Target: PRDM4 (PR Domain Containing 4 (PRDM4))

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Product Details

Purpose: Recombinant PRDM4 protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Recombinant PRDM4 protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Handling Advice: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Storage: -80 °C

Storage Comment: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Target Details

Target: PRDM4 (PR Domain Containing 4 (PRDM4))

Alternative Name: PRDM4

Background:

Protein Background: PRDM4 (PR/SET Domain 4) is a transcription factor of the PR-domain protein family. It contains a PRdomain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. PRDM4 recruits the chromatin modifier PRMT5, an arginine methyltransferase that catalyzes symmetric dimethylation of histone H4 arginine 3 (H4R3me2s) to exerts histone methyltransferase activity. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF). Diseases associated with PRDM4 include Pseudo-Von Willebrand Disease and Porokeratosis.

Short Description: Recombinant PRDM4 protein was expressed in baculovirus expression system as the full length protein (accession number NP_036538.3) with a N-terminal FLAG tag. The molecular weight of the protein is 89.2 kDa.

Aliases: PR/SET Domain 4

Pathways: Neurotrophin Signaling Pathway