RNF4 Protein
Quick Overview for RNF4 Protein (ABIN7939518)
Target
See all RNF4 ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant RNF4 protein
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Ring Finger Protein 4 (RNF4) (AA 1-190) protein (GST tag)
RNF4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Ring Finger Protein 4 (RNF4) (AA 1-190) protein (His tag)RNF4 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Ring Finger Protein 4 (RNF4) proteinRNF4 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant WB, SDS, ELISA, IP
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant RNF4 protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- RNF4 (Ring Finger Protein 4 (RNF4))
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Alternative Name
- RNF4
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Background
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Protein Background: RNF4 (E3 ubiquitin-protein ligase RNF4) also known as RES4-26, SLX5 and SNURF. RNF4 is a E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'- , 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.
Short Description: Recombinant RNF4 protein that includes full length of human RNF4 protein (accession number NP_001171938.1) was expressed in E. coli and contains an N-terminal His tag with a molecular weight of 23.48 kDa. The purity of the protein is ≥ 95 % by SDS-PAGE.
Aliases: E3 ubiquitin-protein ligase RNF4, RES4-26, SLX5, SNURF
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Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway
Target
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