SMAD1 Protein
Quick Overview for SMAD1 Protein (ABIN7939586)
Target
See all SMAD1 ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant SMAD1 protein
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SMAD, Mothers Against DPP Homolog 1 (SMAD1) (AA 1-465) protein (GST tag)
SMAD1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
SMAD, Mothers Against DPP Homolog 1 (SMAD1) (AA 1-110) protein (GST tag)SMAD1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
SMAD, Mothers Against DPP Homolog 1 (SMAD1) (AA 1-250) protein (His tag)SMAD1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant SMAD1 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))
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Alternative Name
- SMAD1
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Background
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Protein Background: SMAD1 is a transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis. Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD1 to form a heteromeric complex which translocates into the nucleus acting as transcription factor. In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network.
Short Description: Recombinant SMAD1 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_005891.1) with an N-terminal FLAG tag. The molecular weight of SMAD1 is 53.53 kDa.
Aliases: JV4-1, MADH1, BSP-1, Mothers Against Decapentaplegic Homolog 1
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Pathways
- Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
Target
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