STUB1 Protein
Quick Overview for STUB1 Protein (ABIN7939612)
Target
See all STUB1 ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant STUB1 / CHIP protein
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STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (GST tag)
STUB1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (His-IF2DI Tag)STUB1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
STIP1 Homology and U-Box Containing Protein 1 (STUB1) protein (Myc-DYKDDDDK Tag)STUB1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant STUB1 / CHIP protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
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Alternative Name
- STUB1 & CHIP
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Background
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Protein Background: STUB1 (E3 ubiquitin-protein ligase CHIP) also known as CHIP, HSPABP2, NY-CO-7, SCA48, SCAR16, SDCCAG7 and UBOX1. STUB1 is a E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates ICER-type isoforms of CREM and targets them for proteasomal degradation, thereby acts as a positive effector of MAPK/ERK-mediated inhibition of apoptosis in cardiomyocytes. Inhibits lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes, via ubiquitination and subsequent proteasomal degradation of NFATC3. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90.
Short Description: Recombinant STUB1 / CHIP protein that includes full length of human STUB1 protein (accession number NP_005852.2) was expressed in E. coli and contains an N-terminal His tag with a molecular weight of 37.02 kDa. The purity of the protein is ≥ 95 % by SDS-PAGE.
Aliases: CHIP, SDCCAG7, UBOX1, E3 Ubiquitin Protein Ligase CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7
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Pathways
- Regulation of Hormone Metabolic Process, Response to Water Deprivation
Target
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