YTHDC2 Protein (full length)

Catalog No. ABIN7939765

Recombinant YTHDC2 protein expressed in Baculovirus infected Insect Cells.

Quick Overview for YTHDC2 Protein (full length) (ABIN7939765)

Target: YTHDC2 (YTH Domain Containing 2 (YTHDC2))

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Application: Screening Assay (ScA), Activity Assay (AcA), Functional Studies (Func)

Product Details

Protein Characteristics: full length

Purpose: Recombinant YTHDC2 protein

Characteristics: Recombinant YTHDC2 protein was expressed in a baculovirus expression system as the full-length protein (accession number NP_073739.3) with an N-terminal Flag tag. The molecular weight of the protein is 161.5 kDa. It is suitable for use in binding assays, inhibitor screening, and selectivity profiling.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Recombinant YTHDC2 protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.

Handling Advice: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Storage: -80 °C

Storage Comment: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Target Details

Target: YTHDC2 (YTH Domain Containing 2 (YTHDC2))

Alternative Name: YTHDC2

Background:

Protein Background: YTHDC2 (YTH Domain Containing 2), is a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. It specifically recognizes and binds to N6-methyladenosine (m6A), a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. YTHDC2 may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line.

Short Description: Recombinant YTHDC2 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_073739.3) with an N-terminal Flag tag. The molecular weight of the protein is 161.5 kDa.

Aliases: YTH Domain Containing 2

Molecular Weight: 161.5 kDa

NCBI Accession: NP_073739