CLDN18.2 (AA 28-76) protein (His tag)

Catalog No. ABIN8056939

This Recombinant CLDN18.2 protein is expressed in Escherichia coli (E. coli).

Quick Overview for CLDN18.2 (AA 28-76) protein (His tag) (ABIN8056939)

Target: CLDN18.2

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 28-76

Purification tag / Conjugate: His tag

Purpose: Recombinant Human CLDN18.2/Claudin-18 A2 Protein (His Tag)

Sequence: Asp28-Leu76

Sterility: 0.2 μm filtered

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 25 mM Tris-HCl, 25 mM NaCl, 0.1 % Triton X-100, 10 % glycerol, 0.1 mM GSH, 0.01 mM GSSG, pH 8.0.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: CLDN18.2

Background: CLDN18,Claudin-18,Claudin-18(CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.

Molecular Weight:

Calculated MW: 19.7 kDa

Observed MW: 18 kDa

Gene ID: 51208

UniProt: P56856