PSMD10 Protein
Quick Overview for PSMD10 Protein (ABIN8057055)
Target
See all PSMD10 ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human Gankyrin/PSDM10 Protein
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Sequence
- Met 1-Gly226
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) (AA 1-226) protein (His tag)
custom-made PSMD10 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) (AA 1-231) protein (His tag)custom-made PSMD10 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) (AA 1-226) protein (GST tag)PSMD10 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) (Transcript Variant 1) proteinPSMD10 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)PSMD10 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of PBS, 10 % Glycerol, pH 7.4.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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Expiry Date
- 6 months
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- PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))
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Alternative Name
- Gankyrin
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Background
- 26S Proteasome Non-ATPase Regulatory Subunit 10,26S Proteasome Regulatory Subunit p28,Gankyrin,PSMD10,p28(GANK),Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.
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Molecular Weight
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Calculated MW: 24.4 kDa
Observed MW: 26 kDa
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Gene ID
- 5716
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UniProt
- O75832
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Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Ubiquitin Proteasome Pathway
Target
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