NCR/Nkp46 Protein

Catalog No. ABIN934901

This Recombinant NCR/Nkp46 protein is produced in Escherichia coli (E. coli).

Quick Overview for NCR/Nkp46 Protein (ABIN934901)

Target: NCR/Nkp46

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Purity: > 95 % pure

Product Details

Sequence: MQQQTLPKPF IWAEPHFMVP KEKQVTICCQ GNYGAVEYQL HFEGSLFAVD RPKPPERINK VKFYIPDMNS RMAGQYSCIY RVGELWSEPS NLLDLVVTEM YDTPTLSVHP GPEVISGEEV TFYCRLDTAT SMFLLLKEGR SSHVQRGYGK VQAEFPLGPV TTAHRGTYRX FGSYNNHAWS FPSEPVKLLV TGDIENTSLA PEDPTFSADT WGTYLLTTET GLQKDHALWD HTAQN

Characteristics: Purified recombinant Human NCR/Nkp46 protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher.

Application Details

Application Notes: NCR/Nkp46 protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Supplied as a liquid in PBS, pH7.4, containing 1 mM EDTA.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: RT/-20 °C

Storage Comment: Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.

Target Details

Target: NCR/Nkp46

Background: A natural cytotoxicity receptor (NCR) NKp46 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. The three known NCRs include NKp46 and NKp30, which are expressed on circulating NKcells, and NKp44, which is expressed only on activating NK cells. NKp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines. NKp46 has two extracellular Ig-like domains followed by a ~40 residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. The extracellular Ig-like domain of NKp46( 22-255aa) was overexpressed in E. coli, and purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer.
Alternative Names: NCR/Nkp-46 protein, NCR protein, Natural killer cell p46-related protein protein, NKp46 protein, LY94 protein, NCR/Nkp-46, hNKp46 protein, NK cell-activating receptor protein, NCR/Nkp 46, NCR1 protein, NK-p46 protein, NCR/Nkp 46 protein, Natural cytotoxicity triggering receptor 1 protein, Natural cytotoxicity triggering receptor 1 isoform a, NKp46 Extracellular Ig-like domain protein, CD335 protein protein, NCR/Nkp46, Lymphocyte protein 94 homolog protein

Molecular Weight: 26.6 kDa (235 AA)