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FEN1 Protein (AA 1-380)

Recombinant FEN1 protein expressed in Escherichia coli (E. coli).
Catalog No. ABIN935077

Quick Overview for FEN1 Protein (AA 1-380) (ABIN935077)

Target

See all FEN1 Proteins
FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))

Protein Type

Recombinant

Origin

  • 7
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Human

Source

  • 40
  • 3
  • 3
  • 2
  • 1
Escherichia coli (E. coli)

Application

SDS-PAGE (SDS)

Purity

> 90 % pure
  • Protein Characteristics

    AA 1-380

    Sequence

    MGIQGLAKLI ADVAPSAIRE NDIKSYFGRK VAIDASMSIY QFLIAVRQGG DVLQNEEGET TSHLMGMFYR TIRMMENGIK PVYVFDGKPP QLKSGELAKR SERRAEAEKQ LQQAQAAGAE QEVEKFTKRL VKVTKQHNDE CKHLLSLMGI PYLDAPSEAE ASCAALVKAG KVYAAATEDM DCLTFGSPVL MRHLTASEAK KLPIQEFHLS RILQELGLNQ EQFVDLCILL GSDYCESIRG IGPKRAVDLI QKHKSIEEIV RRLDPNKYPV PENWLHKEAH QLFLEPEVLD PESVELKWSE PNEEELIKFM CGEKQFSEER IRSGVKRLSK SRQGSTQGRL DDFFKVTGSL SSAKRKEPEP KGSTKKKAKT GAAGKFKRGK

    Characteristics

    Purified recombinant Human FEN1 protein
    Expression System: E.coli
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  • Application Notes

    FEN1 protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    Supplied as a liquid in 20 mM Tris-HCl buffer, pH 8.0, containing 0 mM DTT and 10 % glycerol.

    Preservative

    Dithiothreitol (DTT)

    Precaution of Use

    This product contains Dithiothreitol: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Handling Advice

    Avoid repeated freeze/thaw cycles.

    Storage

    RT/-20 °C

    Storage Comment

    Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.
  • Target

    FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))

    Alternative Name

    FEN1

    Background

    FEN-1, also known as Flap structure-specific endonuclease 1, removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. FEN-1 is highly homologous to yeast Rad2. The C-terminal region of FEN-1 may bind to PCNA, thus allowing FEN-1 to function as an exonuclease in DNA replication. Recombinant human FEN-1 protein was expressed in E. coli and purified by using conventional chromatography techniques.
    Alternative Names: Flap structure specific endonuclease 1 protein, Flap endonuclease 1 protein, Maturation factor 1 protein, MF1 protein, hFEN1 protein, RAD2 protein, FEN 1, FEN-1, Flap structure-specific endonuclease 1 DNase IV protein, FEN 1 protein, FEN-1 protein, FEN-1 protein, , FEN1

    Molecular Weight

    42.5 kDa (380 AA)

    Pathways

    Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA
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