DLL4 Protein
Quick Overview for DLL4 Protein (ABIN935314)
Target
See all DLL4 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- SGVFQLQLQE FINERGVLAS GRPCEPGCRT FFRVCLKHFQ AVVSPGPCTF GTVSTPVLGT NSFAVRDDSS GGGRNPLQLP FNFTWPGTFS LIIEAWHAPG DDLRPEALPP DALISKIAIQ GSLAVGQNWL LDEQTSTLTR LRYSYRVICS DNYYGDNCSR LCKKRNDHFG HYVCQPDGNL SCLPGWTGEY CQQPICLSGC HEQNGYCSKP AECLCRPGWQ GRLCNECIPH NGCRHGTCST PWQCTCDEGW GGLFCDQDLN YCTHHSPCKN GATCSNSGQR SYTCTCRPGY TGVDCELELS ECDSNPCRNG GSCKDQEDGY HCLCPPGYYG LHCEHSTLSC ADSPCFNGGS CRERNQGANY ACECPPNFTG SNCEKKVDRC TSNPCANGGQ CLNRGPSRMC RCRPGFTGTY CELHVSDCAR NPCAHGGTCH DLENGLMCTC PAGFSGRRCE VRTSIDACAS SPCFNRATCY TDLSTDTFVC NCPYGFVGSR CEFPVGLP
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Characteristics
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Purified recombinant Human sDLL4 protein
Expression System: 293 cells
Bioactivity: The sDLL-4, when immobilized at concentrations >1.5 µg/mL will inhibit myogenesis in C2C12 cells. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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delta-Like 4 (DLL4) (AA 27-524) protein (His-Avi Tag,Biotin)
DLL4 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
delta-Like 4 (DLL4) (AA 27-524) protein (Fc Tag)DLL4 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
delta-Like 4 (DLL4) (AA 558-685) protein (His-IF2DI Tag)DLL4 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
delta-Like 4 (DLL4) (Active) protein (His tag)DLL4 Origin: Mouse Host: HEK-293 Cells Recombinant > 96 % as determined by SDS-PAGE Active
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- RT/-20 °C
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- DLL4 (delta-Like 4 (DLL4))
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Alternative Name
- sDLL4
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Background
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Human sDLL4 comprises the extracellular signaling domain of DLL, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. DLL4 functions to specifically activate the Notch-1 and Notch-4 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Targeted deletion of the DLL4 gene in mice resulted in severe vascular defects and death before birth.
Alternative Names: sDLL-4 protein, sDLL 4 protein, sDLL 4, sDLL4, sDLL-4 protein, Delta-like protein 4, Drosophila Delta homolog 4 protein, sDLL-4 -
Molecular Weight
- 54 kDa
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Pathways
- Notch Signaling
Target
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