Epiregulin Protein (EREG)
Quick Overview for Epiregulin Protein (EREG) (ABIN935331)
Target
See all Epiregulin (EREG) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL
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Characteristics
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Purified recombinant Human Epiregulin protein
Expression System: E.coli
Bioactivity: The ED50 was determined by the dose-dependent stimulation of the proliferation of Mouse Balb/3T3 cells is ? 2.0 ng/mL, corresponding to a specific activity of ? 5 x 10^5units/mg. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Epiregulin (EREG) (AA 56-101) protein (Fc Tag)
EREG Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Epiregulin (EREG) (AA 63-108) protein (Fc Tag)EREG Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Epiregulin (EREG) (AA 60-108) protein (His-IF2DI Tag)EREG Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Epiregulin (EREG) (AA 1-169) protein (GST tag)EREG Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- RT/-20 °C
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- Epiregulin (EREG)
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Alternative Name
- Epiregulin
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Background
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Epiregulin is an EGF related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes and in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.
Alternative Names: EREG protein -
Molecular Weight
- 5.6 kDa
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Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation
Target
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