GZMB Protein

Catalog No. ABIN935398

Recombinant GZMB protein expressed in Baculovirus.

Quick Overview for GZMB Protein (ABIN935398)

Target: GZMB (Granzyme B (GZMB))

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: Baculovirus

Purity: > 98 % pure

Product Details

Sequence: IIGGHEVKPH SRPYMALLSI KDQQPEAICG GFLIREDFVL TAAHCEGSII NVTLGAHNIK EQEKTQQVIP MVKCIPHPDY NPKTFSNDIM LLKLKSKAKR TRAVRPLNLP RRNVNVKPGD VCYVAGWGRM APMGKYSNTL QEVELTVQKD RECESYFKNR YNKTNQICAG DPKTKRASFR GDSGGPLVCK KVAAGIVSYG YKDGSPPRAF TKVSSFLSWI KKTMKSS

Characteristics: Purified recombinant Mouse Granzyme B protein
Expression System: Baculovirus
Bioactivity: Determined by its ability to cleave a synthetic chromogentic Granzyme B substrate. The expected specific activity , when using the Ac-IEPD-pNA substrate at 250C, is greater than 750 nM/min per µg of enzyme.

Endotoxin Level: < 0.1 ng per µg (1 EU/µg).

Application Details

Application Notes: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Supplied as a lyophilized powder.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: RT/-20 °C

Target Details

Target: GZMB (Granzyme B (GZMB))

Alternative Name: Granzyme B

Background: Granzyme B is a cysteine protease found in the cytoplasmic granules of cytolytic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme B is required for the induction of target cell lysis, which occurs as part of cell mediated immune responses, and can activate apoptosis in target cells by both caspase dependent and caspase independent mechanisms. Proteolytic cleavage of substrates by Granzyme B takes place primarily after aspartic acid residues. Recombinant Mouse.

Molecular Weight: 28.9 kDa

Pathways: Apoptosis, Caspase Cascade in Apoptosis