HBEGF Protein
Quick Overview for HBEGF Protein (ABIN935466)
Target
See all HBEGF ProteinsProtein Type
Origin
Source
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Characteristics
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Purified recombinant Human HB-EGF protein
Expression System: Spodoptera frugiperda -
Endotoxin Level
- < 1.0 EU per 1 µg of the protein by the LAL method.
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Heparin-Binding EGF-Like Growth Factor (HBEGF) (AA 63-148) protein (His-IF2DI Tag)
HBEGF Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Heparin-Binding EGF-Like Growth Factor (HBEGF) (AA 20-160) protein (Fc Tag)HBEGF Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Heparin-Binding EGF-Like Growth Factor (HBEGF) (AA 24-160) protein (His tag)HBEGF Origin: Mouse Host: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Heparin-Binding EGF-Like Growth Factor (HBEGF) (AA 24-160) protein (Fc Tag)HBEGF Origin: Mouse Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Heparin-Binding EGF-Like Growth Factor (HBEGF) (AA 63-148) (Active) protein (His tag)HBEGF Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- RT/-20 °C
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- HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))
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Alternative Name
- HB-EGF
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Background
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HBEGF was originally purified based on its heparinbinding property and mitogenic activity on BALB3T3 fibroblasts from the conditioned medium of the human U937 histiocytic lymphoma cell line. The natural protein has an apparent molecular mass of 19 23 kDa and exists in multiple forms as a result of heterogenous Oglycosylation and/or Nterminal truncation. In addition to fibroblasts, HB EGF is also a potent mitogen for keratinocytes and smooth muscle cells but not for capillary endothelial cells. HBEGF is produced in monocytes and macrophages. In addition, transcription of HBEGF can be induced in vascular endothelial cells as well as aortic smooth muscle cells (SMC), suggesting that HB EGF may have an important role in the pathogenesis of atherosclerosis.
Alternative Names: Heparin Binding Epidermal Growth Factor protein, HB EGF protein -
Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Target
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