IL-31 Protein
Quick Overview for IL-31 Protein (ABIN935492)
Target
See all IL-31 (IL31) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T
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Characteristics
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Purified recombinant Human IL31 protein
Expression System: E.coli
Bioactivity: Measured by its ability to induce STAT3 activation in human U87 cells. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Interleukin 31 (IL31) (AA 27-163) protein (His tag)
IL31 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 31 (IL31) (AA 24-163) protein (His tag)IL31 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 31 (IL31) (AA 24-164) protein (Fc Tag)IL31 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 31 (IL31) (AA 24-159) protein (His tag)IL31 Origin: Dog Host: Baculovirus infected Insect Cells Recombinant > 95% by SDS-PAGE SDS
Interleukin 31 (IL31) proteinIL31 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant 97,00% SDS
Interleukin 31 (IL31) (AA 24-164) (Active) protein (His tag)IL31 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 31 (IL31) proteinIL31 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant 97,00% SDS
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitute with distilled water to a concentration of 0.1 - 0.5 mg/mL.
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Buffer
- Lyophilized from 10 mM Na3PO4, pH 7.5.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- RT/-20 °C
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- IL-31 (IL31) (Interleukin 31 (IL31))
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Alternative Name
- IL31
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Background
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Human IL31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases.
Alternative Names: Interleukin 31 protein, IL 31, IL 31 protein, IL31, IL-31, IL-31 protein, IL-31 protein -
Molecular Weight
- 15.8 kDa
Target
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