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IGFBP6 Protein

Recombinant IGFBP6 protein expressed in Hi-5 Cells.

Catalog No. ABIN935551

Datasheet as PDF

Quick Overview for IGFBP6 Protein (ABIN935551)

Target

See all IGFBP6 Proteins

IGFBP6 (Insulin-Like Growth Factor Binding Protein 6 (IGFBP6))

Protein Type

Recombinant

Biological Activity

Active

Origin

Human

Source

Hi-5 Cells

Purity

> 95 % pure

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Sequence

RCPGCGQGVQ AGCPGGCVEE EDGGSPAEGC AEAEGCLRRE GQECGVYTPN CAPGLQCHPP KDDEAPLRAL LLGRGRCLPA RAPAVAEENP KESKPQAGTA RPQDVNRRDQ QRNPGTSTTP SQPNSAGVQD TEMGPCRRHL DSVLQQLQTE VYRGAQTLYV PNCDHRGFYR KRQCRSSQGQ RRGPCWCVDR MGKSLPGSPD GNGSSSCPTG SSG

Characteristics

Purified recombinant Human IGF BP6 protein
Expression System: Hi-5 cells
Bioactivity: Determined by its ability to inhibit IGF-II induced proliferation of human MCF-7 cells. The expected ED50 for this effect is 0.1 - 0.4 µg/mL.

Endotoxin Level

< 0.1 ng per µg (1 EU/µg).
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Insulin-Like Growth Factor Binding Protein 6 (IGFBP6) protein (His tag)
IGFBP6 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE

Insulin-Like Growth Factor Binding Protein 6 (IGFBP6) (AA 28-240) protein (His tag)
IGFBP6 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

Insulin-Like Growth Factor Binding Protein 6 (IGFBP6) (AA 26-238) protein (His tag)
IGFBP6 Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 90% by SDS-PAGE SDS

Insulin-Like Growth Factor Binding Protein 6 (IGFBP6) (AA 1-240) protein (GST tag)
IGFBP6 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

Insulin-Like Growth Factor Binding Protein 6 (IGFBP6) protein (His tag)
IGFBP6 Origin: Rat Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE

Insulin-Like Growth Factor Binding Protein 6 (IGFBP6) (Active) protein (His tag)
IGFBP6 Origin: Mouse Host: HEK-293 Cells Recombinant > 92 % as determined by SDS-PAGE Active

Insulin-Like Growth Factor Binding Protein 6 (IGFBP6) (AA 26-238) protein (His tag)
IGFBP6 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.

Insulin-Like Growth Factor Binding Protein 6 (IGFBP6) protein (His tag)
IGFBP6 Origin: Human Host: Escherichia coli (E. coli) Recombinant SDS, WB, ELISA

Insulin-Like Growth Factor Binding Protein 6 (IGFBP6) protein (His-SUMO Tag)
IGFBP6 Origin: Human Host: Escherichia coli (E. coli) Recombinant SDS, WB, ELISA

Insulin-Like Growth Factor Binding Protein 6 (IGFBP6) protein (GST tag,His tag)
IGFBP6 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant SDS, WB, ELISA

Application Notes

Each Investigator should determine their own optimal working dilution for specific applications.

Comment

Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.

Restrictions

For Research Use only
Format

Lyophilized

Buffer

Supplied as a lyophilized powder.

Handling Advice

Avoid repeated freeze/thaw cycles.

Storage

RT/-20 °C
Target

IGFBP6 (Insulin-Like Growth Factor Binding Protein 6 (IGFBP6))

Alternative Name

IGF BP6

Background

IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP6 is produced by bone cells and is the major IGF-BP present in cerebrospinal fluid, and specifically inhibits IGF-II actions. IGF-BP6 has been shown to inhibit IGF-II-dependent cancers such as neuroblastoma, colon cancer and rhabdomyosarcoma.
Alternative Names: IGF BP-6 protein, IBP-6 protein, IGF BP 6, IGF BP6, IGF BP 6 protein, IGF BP-6 protein, IGF BP-6

Molecular Weight

22.6 kDa

Pathways

WNT Signaling, Myometrial Relaxation and Contraction