IGFBP4 Protein
Quick Overview for IGFBP4 Protein (ABIN935568)
Target
See all IGFBP4 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCAL GLGMPCGVYT PRCGSGLRCY PPRGVEKPLH TLMHGQGVCM ELAEIEAIQE SLQPSDKDEG DHPNNSFSPC SAHDRRCLQK HFAKIRDRST SGGKMKVNGA PREDARPVPQ GSCQSELHRA LERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDG QRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LADSFRE
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Characteristics
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Purified recombinant Human IGF BP4 protein
Expression System: Hi-5 cells
Bioactivity: Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Insulin-Like Growth Factor Binding Protein 4 (IGFBP4) (AA 22-258) protein (His-IF2DI Tag)
IGFBP4 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Insulin-Like Growth Factor Binding Protein 4 (IGFBP4) (AA 1-258) (Active) protein (His tag)IGFBP4 Origin: Human Host: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. WB, SDS, Imm, ELISA, AcA Active
Insulin-Like Growth Factor Binding Protein 4 (IGFBP4) (AA 1-258) protein (GST tag)IGFBP4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Comment
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Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- RT/-20 °C
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- IGFBP4 (Insulin-Like Growth Factor Binding Protein 4 (IGFBP4))
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Alternative Name
- IGF BP4
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Background
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IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP4 is the major IGF-BP produced by osteoblasts, and is also found in the epidermis, ovarian follicles, and other tissues. IGF-BP4 inhibits the activity of IGF-I and IGF-II by binding in a manner that results in the formation of complexes with reduced ability to signal through cell surface IGF receptors. IGF-BP4 can inhibit the growth of chick pelvis cartilage and HT29 colon adenocarcinoma cells by blocking the mitogenic actions of IGFs, and has also been shown to reduce colony formation by colorectal cancer cells via an IGF1ndependent pathway.
Alternative Names: Insulin-like Growth Factor-Binding Protein 4 protein, IGF BP-4, IGF BP 4 protein, IBP-4 protein, IGF BP4, colon cancer cell growth inhibitor protein, IGF BP-4 protein, HT29-IGF-BP protein, IGF BP-4 protein, IGF BP 4 -
Molecular Weight
- 25.8 kDa
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Pathways
- WNT Signaling, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process
Target
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