Neuroserpin Protein
Quick Overview for Neuroserpin Protein (ABIN935690)
Target
See all Neuroserpin (SERPINI1) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- MTGATFPEEA IADLSVNMYN RLRATGEDEN ILFSPLSIAL AMGMMELGAQ GSTQKEIRHS MGYDSLKNGE EFSFLKEFSN MVTAKESQYV MKIANSLFVQ NGFHVNEEFL QMMKKYFNAA VNHVDFSQNV AVANYINKWV ENNTNNLVKD LVSPRDFDAA TYLALINAVY FKGNWKSQFR PENTRTFSFT KDDESEVQIP MMYQQGEFYY GEFSDGSNEA GGIYQVLEIP YEGDEISMML VLSRQEVPLA TLEPLVKAQL VEEWANSVKK QKVEVYLPRF TVEQEIDLKD VLKALGITEI FIKDANLTGL SDNKEIFLSK AIHKSFLEVN EEGSEAAAVS GMIAISRMAV LYPQVIVDHP FFFLIRNRRT GTILFMGRVM HPETMNTSGH DFEEL
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Characteristics
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Purified recombinant Human Neuroserpin protein
Expression System: E.coli
Bioactivity: Determined by the dose-dependent stimulation of the proliferation of rat C6 cells using a concentration range of 0.3-0.6 µg/mL. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 17-410) protein (His-IF2DI Tag)
SERPINI1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) protein (His tag)SERPINI1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 17-410) protein (GST tag)SERPINI1 Origin: Human Host: Wheat germ Recombinant AP, AA, ELISA, WB
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- Neuroserpin (SERPINI1) (serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1))
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Alternative Name
- Neuroserpin
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Background
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Neuroserpin is an inhibitory serpin that is expressed predominantly in central nervous system. Although the physiological target of neuroserpin is still unclear, cumulative evidence suggest that it plays an important role in controlling proteolytic degradation of extracellular matrix (ECM) during synaptogenesis and the subsequent development of neuronal plasticity. In the adult brain, neuroserpin is secreted from the growth cones of neurons in areas where synaptic changes are associated with learning and memory, i.e. cerebral cortex, hippocampus, and amygdala.
Alternative Names: Serpin I1 protein, Protease inhibitor 12 protein -
Molecular Weight
- 44.6 kDa
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Pathways
- Regulation of Hormone Metabolic Process
Target
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