TNFSF4 Protein
Quick Overview for TNFSF4 Protein (ABIN935701)
Target
See all TNFSF4 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Characteristics
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Purified recombinant Human OX40 Ligand protein
Expression System: Hi-5 cells
Bioactivity: Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 30-100 ng/mL. Note: Results may vary with PBMC donors. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4) (AA 51-183), (Trimer) (Active) protein (His-DYKDDDDK Tag)
TNFSF4 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4) (AA 99-330) protein (His tag,mFc Tag)TNFSF4 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, AM, ADA, IA
Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4) (AA 52-183) protein (His-DYKDDDDK-Strep II Tag)TNFSF4 Origin: Human Host: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4) (AA 51-198) (Active) protein (hFc Tag)TNFSF4 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4) (AA 1-183) protein (GST tag)TNFSF4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4) protein (His tag)TNFSF4 Origin: Cynomolgus Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4) (AA 51-183) (Active) protein (Fc Tag)TNFSF4 Origin: Rhesus Monkey Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4) (AA 51-183) (Active) protein (AVI tag,Fc Tag,Biotin)TNFSF4 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Comment
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Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- TNFSF4 (Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4))
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Alternative Name
- OX40 Ligand
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Background
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OX40L, a member of the TNF superfamily of structurally related proteins, exists primarily as a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells (APCs), such as dendritic cells and activated B-cells, and also on various other cells such as vascular endothelial cells, mast cells, and natural killer cells. OX40L signals specifically through the OX40 receptor, which is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. OX40/OX40L functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL2, IL3, and IFN.
Alternative Names: OX40 Ligand, OX40L protein, OX Ligand-40, CD252 protein, OX Ligand-40 protein, OX Ligand 40 protein, Gp34 protein, TNFSF4 protein, OX Ligand 40 -
Molecular Weight
- 15.5-25 kDa
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Pathways
- Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation, Cancer Immune Checkpoints
Target
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