Persephin Protein (PSPN)
This Recombinant Persephin protein is produced in Escherichia coli (E. coli).
Catalog No. ABIN935747
Quick Overview for Persephin Protein (PSPN) (ABIN935747)
Target
See all Persephin (PSPN) Proteins
Persephin (PSPN)
Protein Type
Recombinant
Biological Activity
Active
Origin
Human
Source
Escherichia coli (E. coli)
Purity
> 98 % pure
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Sequence
- ALSGPCQLWS LTLSVAELGL GYASEEKVIF RYCAGSCPRG ARTQHGLALA RLQGQGRAHG GPCCRPTRYT DVAFLDDRHR WQRLPQLSAA ACGCGG
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Characteristics
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Purified recombinant Human Persephin protein
Expression System: E.coli
Bioactivity: Human Persephin induces RET phosphorylation using a concentration range of 0.1-1.0 ng/mL. Human Persephin binds to mammalian GFRa4 with the Kd of 100 pM. Other members of the GDNF family (Artemin, GDNF and Neurturin) do not bind to mammalian GFRa4. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Persephin (PSPN) (AA 61-156) protein (His tag)
PSPN Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- Persephin (PSPN)
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Alternative Name
- Persephin
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Background
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Persephin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFR alpha (alpha1-alpha4) receptors. The GFRalpha4 was first identified in chicken and was later shown to be the preferential binding subunit for Persephin. Persephin promotes the survival of ventral midbrain dompaminergic neurons and motor neurons after sciatic nerve oxotomy, and like GNDF, promotes ureteric bud branching. However, in contrast to GDNF and Neurturin, Persephin does not support survival of peripheral neurons.
Alternative Names: PSP protein, PSPN protein
Target
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