Persephin Protein (PSPN)
This Recombinant Persephin protein is expressed in Escherichia coli (E. coli).
Catalog No. ABIN935748
Quick Overview for Persephin Protein (PSPN) (ABIN935748)
Target
See all Persephin (PSPN) Proteins
Persephin (PSPN)
Protein Type
Recombinant
Biological Activity
Active
Origin
Human
Source
Escherichia coli (E. coli)
Purity
> 98 % pure
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Sequence
- ALAGSCRLWS LTLPVAELGL GYASEEKVIF RYCAGSCPQE ARTQHSLVLA RLRGRGRAHG RPCCQPTSYA DVTFLDDQHH WQQLPQLSAA ACGCGG
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Characteristics
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Purified recombinant Human Persephin protein
Expression System: E.coli
Bioactivity: The ED50 was determined by its ability to stimulate proliferation of human thyroid carcinoma cells (TT cells) is 1 x 10^7 units/mg. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Persephin (PSPN) (AA 61-156) protein (His tag)
PSPN Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- Persephin (PSPN)
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Alternative Name
- Persephin
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Background
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Persephin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFRa (a1-a4) receptors. The GFRa4 was first identified in chicken and was later shown to be the preferential binding subunit for Persephin. Persephin promotes the survival of ventral midbrain dompaminergic neurons and motor neurons after sciatic nerve oxotomy, and like GNDF, promotes ureteric bud branching. However, in contrast to GDNF and Neurturin, Persephin does not support survival of peripheral neurons.
Alternative Names: PSPN protein, PSP protein
Target
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