TNFRSF10A Protein
Quick Overview for TNFRSF10A Protein (ABIN935796)
Target
See all TNFRSF10A ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- MSGTGAAAAT PSKVWGSSAG RIEPRGGGRG ALPTSMGQHG PSARARAGRA PGPRPAREAS PRLRVHKTFK FVVVGVLLQV VPSSAATIKL HDQSIGTQQW EHSPLGELCP PGSHRSERPG ACNRCTEGVG YTNASQQLFA CLPCTACKSD EEERSPCTTT RNTACQCKPG TFRNDNSAEM CRKCSTGCPR GMVKVKDCTP WSDIECVHKE SGNGHN
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Characteristics
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Purified recombinant Human TRAIL Receptor 1 protein
Expression System: E.coli
Bioactivity: Determined by its inhibitory effect of IL-8 production in human PBMC by human sTRAIL/Apo2L. 95 % inhibition (100 ng/mL of s TRAIL/Apo2L) was reached using a concentration of 100 ng/mL of sTRAIL Receptor-1. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))
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Alternative Name
- TRAIL Receptor 1
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Background
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TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic death domain, which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L.
Alternative Names: DR4 protein, TRAIL R1 antibody, soluble TRAIL Receptor-1 protein, TNFRSF10A protein, TRAIL Receptor-1 protein, TRAIL R1 antibody, Apo2 protein -
Molecular Weight
- 22.7 kDa
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Pathways
- Apoptosis, Positive Regulation of Endopeptidase Activity
Target
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