SOX2 Protein
Quick Overview for SOX2 Protein (ABIN935801)
Target
See all SOX2 ProteinsProtein Type
Origin
Source
Purity
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Sequence
- MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK LLSETEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLM KKDKYTLPGG LLAPGGNSMA SGVGVGAGLG AGVNQRMDSY AHMNGWSNGS YSMMQDQLGY PQHPGLNAHG AAQMQPMHRY DVSALQYNSM TSSQTYMNGS PTYSMSYSQQ GTPGMALGSM GSVVKSEASS SPPVVTSSSH SRAPCQAGDL RDMISMYLPG AEVPEPAAPS RLHMSQHYQS GPVPGTAING TLPLSHM
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Characteristics
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Purified recombinant Human Sox2 protein
Expression System: E.coli -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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SRY (Sex Determining Region Y)-Box 2 (SOX2) (AA 1-319) protein (His tag)
custom-made SOX2 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
SRY (Sex Determining Region Y)-Box 2 (SOX2) (AA 1-317) protein (His tag)custom-made SOX2 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
SRY (Sex Determining Region Y)-Box 2 (SOX2) (AA 129-317) protein (His-IF2DI Tag)SOX2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
SRY (Sex Determining Region Y)-Box 2 (SOX2) (AA 1-200) protein (His tag)SOX2 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90% by SDS-PAGE SDS
SRY (Sex Determining Region Y)-Box 2 (SOX2) (AA 155-245) protein (GST tag)SOX2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
SRY (Sex Determining Region Y)-Box 2 (SOX2) (AA 1-317) protein (GST tag)SOX2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
SRY (Sex Determining Region Y)-Box 2 (SOX2) protein (Myc-DYKDDDDK Tag)SOX2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))
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Alternative Name
- Sox2
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Background
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Sox2, also known as sex determining region Y (SRY)-box 2, belongs to a diverse family of structurally-related transcription factors whose primary structure contains a 79-residue DNA-binding domain, called high mobility group (HMG) box. It plays an essential role in maintaining the pluripotency of embryonic stem cells (ESC) and determination of cell fate. Microarray analysis showed that Sox2 regulates the expression of multiple genes involved in embryonic development including FGF4, YES1 and ZFP206. Sox2 acts as a transcriptional activator after forming a ternary complex with Oct3/4 and a conserved non-coding DNA sequence (CNS1) located approximately 2 kb upstream of the RAX promoter. The introduction of Sox2, Oct4, Myc, and Klf4, into human dermal fibroblasts isolated from a skin biopsy of a healthy research fellow was sufficient to confer a pluripotent state upon the fibroblast genome.
Alternative Names: Sox-2, Sox-2 protein, Sox 2 protein, Sex Determining Region Y- box 2 protein, Sox2, Sox-2 protein, Sox 2 -
Molecular Weight
- 34.3 kDa
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Pathways
- Dopaminergic Neurogenesis, Sensory Perception of Sound, Stem Cell Maintenance, Cell RedoxHomeostasis
Target
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