PSD10 Protein (AA 1-226, full length) (His-SUMO Tag)
Recombinant PSD10 protein expressed in Escherichia coli (E. coli).
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Catalog No. ABIN5710171
$488.40
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Quick Overview for PSD10 Protein (AA 1-226, full length) (His-SUMO Tag) (ABIN5710171)
Target
PSD10
(26S Proteasome Non-ATPase Regulatory Subunit 10 (PSD10))
Protein Type
Recombinant
Origin
Human
Source
Escherichia coli (E. coli)
Application
SDS-PAGE (SDS)
Purity
Greater than 90 % as determined by SDS-PAGE.
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Protein Characteristics
- full length, AA 1-226
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Purification tag / Conjugate
- This PSD10 protein is labelled with His-SUMO Tag.
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Purpose
- Recombinant Human 26S proteasome non-ATPase regulatory subunit 10(PSMD10)
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Sequence
- MEGCVSNLMV CNLAYSGKLE ELKESILADK SLATRTDQDS RTALHWACSA GHTEIVEFLL QLGVPVNDKD DAGWSPLHIA ASAGRDEIVK ALLGKGAQVN AVNQNGCTPL HYAASKNRHE IAVMLLEGGA NPDAKDHYEA TAMHRAAAKG NLKMIHILLY YKASTNIQDT EGNTPLHLAC DEERVEEAKL LVSQGASIYI ENKEEKTPLQ VAKGGLGLIL KRMVEG
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Characteristics
- N-terminal 6xHis-SUMO-tagged
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 0.1-2 mg/mL
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Buffer
- Tris-based buffer50 % glycerol
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Storage
- -20 °C,-80 °C
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Storage Comment
- The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
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Expiry Date
- 6-12 months
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- PSD10 (26S Proteasome Non-ATPase Regulatory Subunit 10 (PSD10))
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Alternative Name
- PSD10
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Background
- Acts as a chaperone during the assbly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assbly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assbles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.
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Molecular Weight
- 40.4 kDa
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Gene ID
- 5716
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UniProt
- O75832
Target
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