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REST Products

(RE1-Silencing Transcription Factor (REST))
This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010].

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Featured REST Categories

REST Antibodies

High quality antibodies with extensive validation data.

REST ELISA Kits

Reliable ELISA kits for a wide range of species.

REST Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended REST Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IF (cc), IF (p), IHC (fro), IHC (p), WB
Validations
  • (3)
  • (6)
Cat. No. ABIN747683
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application WB
Validations
  • (1)
  • (6)
Cat. No. ABIN2779670
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IP, WB
Validations
  • (3)
Cat. No. ABIN7269883
Quantity 100 μL
Datasheet Datasheet

Recommended REST ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6975568
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969840
Quantity 96 tests
Datasheet Datasheet
Reactivity Chicken
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6235985
Quantity 96 tests
Datasheet Datasheet

Recommended REST Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3095008
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3136764
Quantity 1 mg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN2751253
Quantity 5 applications
Datasheet Datasheet

Latest Publications for our REST products

Li, Cheng, Xu, Zhang, Tokat, Dolios, Ramakrishnan, Shen, Wang, Xu: "The transcriptional coactivator Eya1 exerts transcriptional repressive activity by interacting with REST corepressors and REST-binding sequences to maintain nephron progenitor identity." in: Nucleic acids research, Vol. 50, Issue 18, pp. 10343-10359, (2022) (PubMed).

Li, Liu, Wu, Chen, Wang, Wang, Huang, Wang, Yu, Fei, Huang: "The deficiency of NRSF/REST enhances the pro-inflammatory function of astrocytes in a model of Parkinson's disease." in: Biochimica et biophysica acta. Molecular basis of disease, Vol. 1866, Issue 1, pp. 165590, (2020) (PubMed).

Ashton, Hye, Leckey, Jones, Gardner, Elliott, Wetherell, Lenze, Killick, Marchant: "Plasma REST: a novel candidate biomarker of Alzheimer's disease is modified by psychological intervention in an at-risk population." in: Translational psychiatry, Vol. 7, Issue 6, pp. e1148, (2018) (PubMed).

Lu, Tran, Park, Chen, Lan, Xie, Semenza: "Reciprocal Regulation of DUSP9 and DUSP16 Expression by HIF1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment." in: Cancer research, Vol. 78, Issue 15, pp. 4191-4202, (2018) (PubMed).

Zhang, Wang, Lu, Wang, Yuan, Yan, Cai, Chang, Zheng, Wu, Zhou: "REST regulates the cell cycle for cardiac development and regeneration." in: Nature communications, Vol. 8, Issue 1, pp. 1979, (2018) (PubMed).

Zhang, Wu, Wang, Wang, Lu, Nechiporuk, Floss, Greally, Zheng, Zhou: "Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts." in: Nucleic acids research, Vol. 45, Issue 6, pp. 3102-3115, (2017) (PubMed).

Perera, Eisen, Wagner, Laube, Künzel, Koch, Steinbacher, Schulze, Splith, Mittermeier, Müller, Biel, Carell, Michalakis: "TET3 is recruited by REST for context-specific hydroxymethylation and induction of gene expression." in: Cell reports, Vol. 11, Issue 2, pp. 283-94, (2015) (PubMed).

Mehta, Kim, Vemuganti: "Long Noncoding RNA FosDT Promotes Ischemic Brain Injury by Interacting with REST-Associated Chromatin-Modifying Proteins." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 50, pp. 16443-9, (2015) (PubMed).

Kashiwagi, Ishii, Sakaeda, Arimasu, Shimoyamada, Sato, Miyata, Kamma, Aoki, Yazawa: "Differences of molecular expression mechanisms among neural cell adhesion molecule 1, synaptophysin, and chromogranin A in lung cancer cells." in: Pathology international, Vol. 62, Issue 4, pp. 232-45, (2012) (PubMed).

Synonyms and alternative names related to REST

RE1 silencing transcription factor (REST), RE1-silencing transcription factor (Rest), RE1-silencing transcription factor S homeolog (rest.S), RE1-silencing transcription factor (REST), RE1-silencing transcription factor (rest), RE1-silencing transcription factor (LOC615792), RE1 silencing transcription factor (rest), 2610008J04Rik, AA407358, NRSF, nrsf, rest, REST, resta, XBR, xbr

Protein level used designations for REST

  • neural-restrictive silencer factor
  • neuron restrictive silencer factor
  • repressor binding to the X2 box
  • zinc finger transcription factor REST protein
  • RE1-silencing transcription factor B
  • RE1-silencing transcription factor a
  • neural-restrictive silencer factor B
  • RE1-silencing transcription factor
  • RE-1 silencer of transcription
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