Efficacy of a Broadly Neutralizing Monoclonal Antibody Against Mpox in Non-Human Primates
NIH View original grantSUMMARY Mpox (Monkeypox virus, MPXV) has become a global health threat, yet current prevention and treatment tools remain inadequate. The JYNNEOS vaccine offers limited protection, and Tecovirimat, the only antiviral tested in humans, has failed in clinical trials. There are currently no approved monoclonal antibody (mAb) therapies for mpox or any orthopoxvirus. This project proposes to develop and evaluate EV35-6, a potent mAb targeting A35, a critical MPXV protein involved in viral disseminati
Matching Reagent Categories (8)
Orthopoxvirus A35 Ortholog Proteins
A35 ortholog proteins from Variola, Vaccinia, Cowpox, and multiple MPXV clades for cross-reactivity and breadth-of-binding studies with EV35-6-like antibodies.
2 products found
Affinity Binding Assay Reagents for A35
Binding assay reagents for measuring antibody-antigen affinity and kinetics, including applications such as interferometry-based characterization of EV35-6 interactions with A35.
3 products found
Recombinant A35 Proteins
Recombinant MPXV A35 antigen and related proteins for antibody screening, epitope mapping, affinity assays, and immunoassay development.
3 products found
Orthopoxvirus Neutralization Assay Reagents
Reagents for in vitro neutralization and plaque-based antiviral assays to evaluate functional activity of anti-A35 antibodies against MPXV and related orthopoxviruses.
3 products found
ELISA Kits and Reagents for Anti-A35 Antibody Detection
Competition ELISA-compatible reagents to detect EV35-6-like antibodies in serum and assess correlations between antibody presence and protection in non-human primate studies.
1 products found
Recombinant A35 Proteins and Orthologs
Recombinant A35 antigens from MPXV and orthologous proteins from Variola, Vaccinia, and Cowpox for cross-reactivity, epitope mapping, and binding breadth assays.
3 products found
Pharmacokinetic Assay Reagents for Human IgG Monoclonal Antibodies
Assay reagents to quantify circulating therapeutic IgG, support bioavailability studies, and compare intravenous versus subcutaneous delivery in rhesus macaque models.
3 products found
Orthopoxvirus Binding Assay Reagents
Affinity binding assay reagents for measuring antibody interactions with A35 across multiple orthopoxviruses, including different MPXV clades and related poxviruses.
3 products found
