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Characterization of pan-fungal monoclonal antibodies targeting Aspergillus

NIH View original grant

The fungal pathogen Aspergillus poses a significant health threat to individuals with weakened immune systems, pre-existing lung disease, and pulmonary co-infections, causing an estimated 2.1 million cases of life-threatening invasive aspergillosis (IA) annually, and approximately 1.8 million deaths (85% mortality). Recent estimates indicate that the frequency of IA has dramatically risen both domestically and globally in recent decades. Even with medical treatment, IA has a disproportionally hi

Matching Reagent Categories (10)

Anti-NXT-2 Monoclonal Antibodies

Monoclonal antibodies against NXT-2 for characterizing epitope specificity, binding strength, and antifungal activity against Aspergillus, especially A. fumigatus.

7 products found

anti-Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) (AA 110-180) antibody (ABIN6144977)

anti-Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) (AA 37-142) antibody (ABIN7570572)

anti-Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) antibody (ABIN7135371)

anti-Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) antibody (ABIN7117024)

anti-Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) antibody (ABIN7812469)

Anti-Aspergillus Surface Antigen Antibodies

Antibodies recognizing Aspergillus cell-surface antigens for binding assays, surface localization studies, and comparison with NXT-2-directed antifungal antibodies.

1 products found

anti-Aspergillus Fumigatus antibody (ABIN5026886)

Opsonophagocytic Killing Assay Reagents for Aspergillus

Reagents to support opsonophagocytic killing assays, including fungal targets and immunologic assay components for testing antibody-mediated enhancement of Aspergillus clearance in vitro.

1 products found

anti-Aspergillus Fumigatus antibody (ABIN5026886)

NXT-2 Recombinant Proteins and Peptides

Recombinant NXT-2 antigen and overlapping peptide fragments for epitope mapping, antibody binding studies, and defining antifungal epitopes recognized by candidate mAbs.

13+ products found

Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) (AA 1-142) protein (His tag) (ABIN7557241)

Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) (AA 1-142) protein (His tag) (ABIN7550198)

Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) (AA 1-197) protein (His tag) (ABIN667694)

Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) (AA 1-197) protein (His-IF2DI Tag) (ABIN7124218)

Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) protein (His tag) (ABIN7578591)

Anti-NXT-2 Monoclonal Antibodies

Monoclonal antibodies against NXT-2 for characterizing epitope specificity, binding strength, and antifungal activity against Aspergillus, especially A. fumigatus.

7 products found

anti-Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) (AA 110-180) antibody (ABIN6144977)

anti-Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) (AA 37-142) antibody (ABIN7570572)

anti-Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) antibody (ABIN7135371)

anti-Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) antibody (ABIN7117024)

anti-Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) antibody (ABIN7812469)

Aspergillus fumigatus Binding and Opsonophagocytic Killing Assay Reagents

Reagents for in vitro binding and opsonophagocytic killing studies with A. fumigatus, including tools suitable for evaluating antibody-mediated fungal clearance mechanisms.

1 products found

anti-Aspergillus Fumigatus antibody (ABIN5026886)

Epitope Mapping Kits for Antibody Characterization

Products for fine epitope mapping and antibody-antigen interaction analysis to define NXT-2 antifungal epitopes and rank monoclonal antibodies by specificity and affinity-related properties.

1 products found

Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) ELISA Kit (ABIN6234685)

Murine Immunoglobulin Isotype Controls and Secondary Antibodies

Mouse antibody isotype controls and detection reagents for validating anti-NXT-2 monoclonal antibody binding in ELISA, flow cytometry, microscopy, or other in vitro immunoassays.

743+ products found

Goat anti-Mouse IgG (Heavy & Light Chain) antibody (TRITC) - Preadsorbed (ABIN101771)

Goat anti-Mouse IgG (Heavy & Light Chain) antibody (PE) - Preadsorbed (ABIN376444)

Donkey anti-Mouse IgG (Heavy & Light Chain) antibody (DyLight 488) (ABIN7446361)

Donkey anti-Mouse IgG (Heavy & Light Chain) antibody (DyLight 488) - Preadsorbed (ABIN7446371)

Goat anti-Mouse IgG (Heavy & Light Chain) antibody (DyLight 488) (ABIN7446789)

ELISA and Binding Assay Kits for Antibody Characterization

Assay kits and reagents for measuring antibody-antigen binding, affinity, and specificity during down-selection of NXT-2 monoclonal antibodies with the strongest anti-Aspergillus activity.

1 products found

Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) ELISA Kit (ABIN6234685)

NXT-2 Recombinant Proteins and Peptides

Recombinant NXT-2 antigen and overlapping peptide fragments for epitope mapping, antibody binding studies, and defining antifungal epitopes recognized by protective antibodies.

13+ products found

Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) (AA 1-142) protein (His tag) (ABIN7557241)

Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) (AA 1-142) protein (His tag) (ABIN7550198)

Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) (AA 1-197) protein (His tag) (ABIN667694)

Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) (AA 1-197) protein (His-IF2DI Tag) (ABIN7124218)

Nuclear Transport Factor 2-Like Export Factor 2 (NXT2) protein (His tag) (ABIN7578591)

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