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These results reveal that CRTAM is critical to instruct the differentiation of CD4 (show CD4 Proteins)(+)CTL through the induction of Eomes (show EOMES Proteins) and CTL-related gene.
CRTAM is negatively regulated by ZEB1 in T cells.
Case-control studies reveal malignant mesothelioma risk associated with variants in the SDK1, CRTAM and RASGRF2 (show RASGRF2 Proteins) genes.
The cell adhesion molecule (show MCAM Proteins) Necl-2 (show CADM1 Proteins) competitively binds the immune receptor CRTAM.
The expression of CRTAM in activated Vgamma9Vdelta2 T cells is quickly downregulated following interaction with Necl-2 (show CADM1 Proteins) on tumor cells.
Three common variants in the class I MHC-restricted T cell-associated molecule gene were identified that were associated with an increased rate of asthma exacerbations based on the presence of a low circulating vitamin D level.
Results show that CRTAM is a molecule involved in epithelial cell adhesion.
Necl2 (show CADM1 Proteins)/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system
NK cells and T8 cells recognize Necl-2 (show CADM1 Proteins) through CRTAM, expressed only on activated cells. CRTAM-Necl-2 (show CADM1 Proteins) interactions promote cytotoxicity of NK cells and IFN-gamma (show IFNG Proteins) secretion of T8 cells as well as NK cell-mediated rejection of tumors expressing Necl-2 (show CADM1 Proteins)
CRTAM expression is driven by the JNK (show MAPK8 Proteins)-AP-1 (show FOSB Proteins) signaling pathway.
During pathogenic infection, Crtam-Cadm1 (show CADM1 Proteins) interactions regulate the dynamic equilibrium between newly formed CD4 (show CD4 Proteins)(+) T cells and their retention in the gut (show GUSB Proteins).
TCS upregulated the expression of tumor suppressor in lung cancer 1 (TSLC1 (show CADM1 Proteins)) in 3LL tumor cells and the expression of its ligand, class I-restricted T cell-associated molecule (CRTAM), in effector T cells.
In reciprocal crosses involving alcohol-preferring and alcohol-avoiding mouse strains, Crtam is identified as a candidate gene for alcohol preference.
show that CRTAM has an unexpected constitutive expression in adult thymocytes and, remarkably, it is sustained during all stages of thymocyte development.
CRTAM expression is critical for the accumulation of antigen-specific cytotoxic T lymphocytes and their subsequent proliferation within the draining lymph node.
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A\; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008
cytotoxic and regulatory T-cell molecule
, thymocyte activation and development protein
, thymocyte activation and developmental protein
, cytotoxic and regulatory T cell molecule
, class-I MHC-restricted T cell associated molecule
, cytotoxic and regulatory T-cell molecule-like
, class I MHC restricted T cell associated molecule
, class-I MHC-restricted T-cell-associated molecule
, class I-restricted T cell-associated molecule