CRTAM Protein (AA 17-289) (His tag)
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- Target See all CRTAM Proteins
- CRTAM (Cytotoxic and Regulatory T Cell Molecule (CRTAM))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 17-289
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This CRTAM protein is labelled with His tag.
- Purpose
- Mouse CRTAM Protein
- Sequence
- Ala17-Gly289
- Characteristics
- Recombinant Mouse CRTAM Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ala17-Gly289.
- Purity
- > 95 % as determined by Tris-Bis PAGE
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Top Product
- Discover our top product CRTAM Protein
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Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) protein (Fc Tag)
CRTAM Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) protein (His tag)CRTAM Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) protein (His tag)CRTAM Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) protein (His tag)CRTAM Origin: Dog Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 1-393) protein (GST tag)CRTAM Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 17-285) protein (His tag)Crystallography grade CRTAM Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-393) protein (rho-1D4 tag)Crystallography grade CRTAM Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 17-389) protein (rho-1D4 tag)Crystallography grade CRTAM Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- CRTAM (Cytotoxic and Regulatory T Cell Molecule (CRTAM))
- Alternative Name
- CRTAM (CRTAM Products)
- Synonyms
- TAD Protein, cTADS Protein, MGC82176 Protein, CRTAM Protein, CD355 Protein, cytotoxic and regulatory T-cell molecule Protein, cytotoxic and regulatory T-cell molecule L homeolog Protein, cytotoxic and regulatory T cell molecule Protein, CRTAM Protein, crtam.L Protein, Crtam Protein
- Background
- Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile, therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis.
- Molecular Weight
- 31.1 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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