Protein Summary

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.

Alternative names and synonyms associated with HLA Class I Histocompatibility Antigen, alpha Chain E (HLA-E)

• major histocompatibility complex, class I, E (HLA-E) antibody
• major histocompatibility complex, class I, E (PATR-E) antibody

• EA1.2 antibody
• EA2.1 antibody
• HLA-6.2 antibody
• MHC antibody
• QA1 antibody

Protein level used designations for HLA-E

HLA class I histocompatibility antigen, E alpha chain , HLA class I histocompatibility antigen, alpha chain E , MHC HLA-E alpha-1 , MHC HLA-E alpha-2.1 , MHC class I antigen E , lymphocyte antigen , patr class I histocompatibility antigen, alpha chain E