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HLA-E Products

(HLA Class I Histocompatibility Antigen, alpha Chain E (HLA-E))

Categories

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008].

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Featured HLA-E Categories

HLA-E Antibodies

High quality antibodies with extensive validation data.

HLA-E ELISA Kits

Reliable ELISA kits for a wide range of species.

HLA-E Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended HLA-E Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p), WB
Validations
  • (2)
  • (4)
Cat. No. ABIN674334
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application FACS, WB
Validations
  • (4)
Cat. No. ABIN516523
Quantity 50 μg
Datasheet Datasheet
Reactivity Human, Non-Human Primate
Application FACS, IHC (p), IP
Validations
  • (5)
  • (2)
Cat. No. ABIN94354
Quantity 0.1 mg
Datasheet Datasheet

Recommended HLA-E ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (3)
  • (1)
Cat. No. ABIN6956585
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6962563
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
  • (1)
Cat. No. ABIN809033
Quantity 96 tests
Datasheet Datasheet

Recommended HLA-E Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3096555
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5710770
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1989653
Quantity 25 μg
Datasheet Datasheet

Latest Publications for our HLA-E products

Goel, Kabeerdoss, Mohan, Danda, Jayaseelan, Kumar, Jude, Bacon, Joseph, Danda: "Soluble-HLA-E: A follow up biomarker in Takayasu arteritis, independent of HLA-E genotype." in: International journal of rheumatic diseases, Vol. 21, Issue 2, pp. 532-540, (2018) (PubMed).

Li, Chen, Xu, Liu, Li, Liu, Wang, Sun, Sheng, Kong: "Alamandine attenuates sepsis-associated cardiac dysfunction via inhibiting MAPKs signaling pathways." in: Life sciences, Vol. 206, pp. 106-116, (2018) (PubMed).

Sun, Xu, Huang, Huang, Wen, Zhang, Wang, Song, Zheng, Sun, Wei, Xiao, Sun, Tian: "High NKG2A expression contributes to NK cell exhaustion and predicts a poor prognosis of patients with liver cancer." in: Oncoimmunology, Vol. 6, Issue 1, pp. e1264562, (2017) (PubMed).

Guo, Lv, Wang, Shi, Yang, Zheng, Wen, Yang: "Predictive value of HLA-G and HLA-E in the prognosis of colorectal cancer patients." in: Cellular immunology, Vol. 293, Issue 1, pp. 10-6, (2015) (PubMed).

Nachmani, Zimmermann, Oiknine Djian, Weisblum, Livneh, Khanh Le, Galun, Horejsi, Isakov, Shomron, Wolf, Hengel, Mandelboim: "MicroRNA editing facilitates immune elimination of HCMV infected cells." in: PLoS pathogens, Vol. 10, Issue 2, pp. e1003963, (2014) (PubMed).

Platonova, Cherfils-Vicini, Damotte, Crozet, Vieillard, Validire, André, Dieu-Nosjean, Alifano, Régnard, Fridman, Sautès-Fridman, Cremer: "Profound coordinated alterations of intratumoral NK cell phenotype and function in lung carcinoma." in: Cancer research, Vol. 71, Issue 16, pp. 5412-22, (2011) (PubMed).

Allard, Oger, Vignard, Percier, Fregni, Périer, Caignard, Charreau, Bernardeau, Khammari, Dréno, Gervois: "Serum soluble HLA-E in melanoma: a new potential immune-related marker in cancer." in: PLoS ONE, Vol. 6, Issue 6, pp. e21118, (2011) (PubMed).

Kuo, Yu, Juo, Yang, Wang, Liang, Chen, Chang, Huang, Lee, Lin, Liu, Guo, Chiu, Chang: "CASP3 gene single-nucleotide polymorphism (rs72689236) and Kawasaki disease in Taiwanese children." in: Journal of human genetics, Vol. 56, Issue 2, pp. 161-5, (2011) (PubMed).

Lo Monaco, Tremante, Cerboni, Melucci, Sibilio, Zingoni, Nicotra, Natali, Giacomini: "Human leukocyte antigen E contributes to protect tumor cells from lysis by natural killer cells." in: Neoplasia (New York, N.Y.), Vol. 13, Issue 9, pp. 822-30, (2011) (PubMed).

Soni, Karande: "Glycodelin A suppresses the cytolytic activity of CD8+ T lymphocytes." in: Molecular immunology, Vol. 47, Issue 15, pp. 2458-66, (2010) (PubMed).

Synonyms and alternative names related to HLA-E

major histocompatibility complex, class I, E (HLA-E), major histocompatibility complex, class I, E (PATR-E), EA1.2, EA2.1, HLA-6.2, MHC, QA1

Protein level used designations for HLA-E

  • HLA class I histocompatibility antigen, E alpha chain
  • HLA class I histocompatibility antigen, alpha chain E
  • MHC HLA-E alpha-1
  • MHC HLA-E alpha-2.1
  • MHC class I antigen E
  • lymphocyte antigen
  • patr class I histocompatibility antigen, alpha chain E
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