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HLA-E antibody

HLA-E Reactivity: Human FACS, ELISA, IP Host: Mouse Monoclonal 3D12 unconjugated
Catalog No. ABIN7013920
  • Target See all HLA-E Antibodies
    HLA-E (HLA Class I Histocompatibility Antigen, alpha Chain E (HLA-E))
    Reactivity
    • 66
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 44
    • 23
    Mouse
    Clonality
    • 46
    • 21
    Monoclonal
    Conjugate
    • 30
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This HLA-E antibody is un-conjugated
    Application
    • 42
    • 26
    • 18
    • 13
    • 13
    • 12
    • 8
    • 7
    • 3
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), ELISA, Immunoprecipitation (IP)
    Specificity
    The mouse monoclonal antibody 3D12 (also known as 3D12HLA-E) recognizes native extracellular part of HLA-E, an ubiquitously expressed non-classical MHC class I molecule, as well as free HLA-E.
    Purification
    Purified by protein-A affinity chromatography.
    Immunogen
    recombinant human HLA-E
    Clone
    3D12
    Isotype
    IgG1
    Top Product
    Discover our top product HLA-E Primary Antibody
  • Application Notes
    Flow cytometry: Recommended dilution: 1-4 μg/mL.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze.
  • Target
    HLA-E (HLA Class I Histocompatibility Antigen, alpha Chain E (HLA-E))
    Alternative Name
    HLA-E (HLA-E Products)
    Synonyms
    EA1.2 antibody, EA2.1 antibody, HLA-6.2 antibody, MHC antibody, QA1 antibody, major histocompatibility complex, class I, E antibody, HLA-E antibody, PATR-E antibody
    Background
    Major histocompatibility complex, class I, E,HLA-E (human leukocyte antigen E) is a non-classical MHC I antigen, which is important for dialogue with NK cells and their regulation through interaction with CD94/NKG2 receptor. Like other MHC I molecules, transmembrane HLA-E molecule (45 kDa) associates with beta2 microglobulin. Unlike HLA-G, expression of HLA-E molecules is not so restricted, but it has been detected at least at mRNA level in virtually all cells and tissues examined. In peripheral blood, HLA-E protein is expressed at least in all mononuclear cells, but in different quantity (B cells and monocytes more than T cells and NK cells).,HLA class I histocompatibility antigen, alpha chain E, MHC class I antigen E
    Gene ID
    3133
    UniProt
    P13747
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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