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The authors demonstrated that mutant NKp46 W32R is aberrantly glycosylated, accumulates in the endoplasmic reticulum, and is unstable on the cell surface.
Low NKp46 expression on on NK cells is associated with Nasopharyngeal Carcinoma.
Signaling via the natural killer cell receptor NKp46 (human) and Ncr1 (mouse) induced interferon-gamma (IFN-gamma (show IFNG Proteins)) secretion from intratumoral natural killer cells.
findings show HIV reservoir size is dependent on the presence of a defined NK cell population with a specific transcriptional signature: high NCR (NKp46 and NKp30 (show NCR3 Proteins)) and IFN-gamma (show IFNG Proteins) inducibility upon NCR and cytokine receptor (show EBI3 Proteins) engagement
NKp46 cleavage by Cathepsin G (show CTSG Proteins) severely impairs NKp46-mediated responses of Natural killer cells.
The NKp46 and NKp46-ligand interaction contributes to NK cell activation.
this study shows that the NKp46-activating receptor recognizes an unknown ligand expressed by human metapneumovirus-infected cells
Intrahepatic NKp46 NK cells exhibited anti-HCV activity via cell-to-cell contact. The variation of the NKp46 proportion in individuals could be attributed to the diversity of HCV resistance observed in these individuals.
Taken together, these results demonstrate that endogenous levels of IFN-alpha (show IFNA Proteins) secreted by plasmacytoid dendritic cells induce natural killer cells to lyse HIV-1-infected autologous CD4 (show CD4 Proteins)+ primary T cells via the engagement of NKp46 and NKG2D (show KLRK1 Proteins).
NKp46 was thus involved in the production of serine proteases and interleukin-22 (show IL22 Proteins) in human mast cells.
Signaling via the natural killer cell receptor NKp46 (human) and Ncr1 (mouse) induced interferon-gamma (IFN-gamma (show IFNG Proteins)) secretion from intratumoral natural killer cells
these studies strongly support roles for NCR1 and its ligands in normal pregnancy promotion
Ly49E-positive population is negative for NKp46 and CD8alphaalpha, expresses CD49a (show ITGA1 Proteins) and CD103 (show ITGAE Proteins), and requires T-bet expression and IL-15 (show IL15 Proteins) signaling for differentiation and/or survival.
this study demonstrates the role of NCR1 in antibody response to mouse cytomegalovirus infection
Our findings uncover a detrimental role of T-bet-dependent NKp46(+) ILCs in the development of CNS autoimmune disease.
The results identify an unexpected phenotypic instability within NKp46(+) ILC3 that suggests a major role for environmental signals in tuning ILC3 functional plasticity.
The authors delineated the fungal ligands to be the Candida glabrata adhesins Epa1, Epa6 (show Epha6 Proteins), and Epa7 and demonstrated that clearance of systemic Candida glabrata infections in vivo depends on their recognition by mouse NCR1.
it is demonstrated that NCR1 dampens allergic eosinophilic airway inflammation.
this study using Ncr1-deficient mice, shows that NCR1 plays a critical role in controlling human metapneumovirus infection
Rag knockout mice that possess fully functional NKp46(+) cells
these data indicate that NKp46 is not expressed by all porcine NK cells and that NKp46 discriminates porcine NK cells differing in regard to cytokine production, which challenges the paradigm of NKp46 as a comprehensive marker for NK cells across different mammalian species.
has similarity to immunoglobulins\; expressed in NK cells
NK cell-activating receptor
, lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46)
, natural killer cell p46-related protein
, MAR1 (mouse activating receptor 1)
, activating receptor 1
, lymphocyte antigen 94
, NK receptor KILR-1
, lymphocyte antigen 94 homolog (activating NK-receptor
, rat-activating receptor 1