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this paper shows that the decreased expression of activating receptor NKp46 on peripheral blood NK cells is positively associated with gastric cancer progression
HIF-1alpha inhibits NCR1/NKp46 pathway through up-regulating miR-224, which affects the killing capability of NK cells on prostate cancer, thus inducing immune escape of tumor cells.
The authors demonstrated that mutant NKp46 W32R is aberrantly glycosylated, accumulates in the endoplasmic reticulum, and is unstable on the cell surface.
Low NKp46 expression on on NK cells is associated with Nasopharyngeal Carcinoma.
Signaling via the natural killer cell receptor NKp46 (human) and Ncr1 (mouse) induced interferon-gamma (IFN-gamma) secretion from intratumoral natural killer cells.
findings show HIV reservoir size is dependent on the presence of a defined NK cell population with a specific transcriptional signature: high NCR (NKp46 and NKp30) and IFN-gamma inducibility upon NCR and cytokine receptor engagement
NKp46 cleavage by Cathepsin G severely impairs NKp46-mediated responses of Natural killer cells.
The NKp46 and NKp46-ligand interaction contributes to NK cell activation.
this study shows that the NKp46-activating receptor recognizes an unknown ligand expressed by human metapneumovirus-infected cells
Intrahepatic NKp46 NK cells exhibited anti-HCV activity via cell-to-cell contact. The variation of the NKp46 proportion in individuals could be attributed to the diversity of HCV resistance observed in these individuals.
Taken together, these results demonstrate that endogenous levels of IFN-alpha secreted by plasmacytoid dendritic cells induce natural killer cells to lyse HIV-1-infected autologous CD4+ primary T cells via the engagement of NKp46 and NKG2D.
NKp46 was thus involved in the production of serine proteases and interleukin-22 in human mast cells.
Age and CMV serostatus influence the expression of NKp30, NKp46 and DNAM-1 activating receptors on resting and IL-2 activated natural killer cells.
Ncr1-Noe proteins accumulate in the endoplasmic reticulum, and that the expression of Ncr1-Noe proteins, but not WT Ncr1, leads to increased Helios expression
Data show that regulatory dendritic cells (regDC) restrain IFN-gamma secretion by NK cells through secretion of interleukin-10 (IL-10), engagement of MHC class I-specific inhibitory receptors, and the activating receptor NKp46.
Expression of NKp46/NCR1 in NK cells was significantly higher in untreated severe aplastic anemia patients than those in remission SAA and controls. This may be the reason for the hyperfunction of the immune system in SAA patients.
On CD56(+) CD3(-) cells, NKp44 and NKp46 expressions were high in the acute hepatitis E patients, whereas NKp30, NKp44, NKp46 and NKG2D were high in the recovered individuals.
Downregulated NKG2D, NKp46, and DNAM-1 receptors associated with impaired NK cell effector function are important biomarkers of advanced disease with a poor prognosis in melanoma patients.
Women, w/ or w/o endometriosis, having larger populations of cytotoxic CD16(+) uterine NK cells and/or higher populations of NKp46(+)CD56(+) cells may be at greater risk of infertility resulting from inflammatory environment during implantation or later
IL-15+IL-12 has an immunomodulatory effect on NK cell subsets from HIV-infected individuals viz down-regulation of iNKRs, elevation of activatory receptors NKp46 and NKG2D, and induction of coreceptor NKp80.
Signaling via the natural killer cell receptor NKp46 (human) and Ncr1 (mouse) induced interferon-gamma (IFN-gamma) secretion from intratumoral natural killer cells
these studies strongly support roles for NCR1 and its ligands in normal pregnancy promotion
Ly49E-positive population is negative for NKp46 and CD8alphaalpha, expresses CD49a and CD103, and requires T-bet expression and IL-15 signaling for differentiation and/or survival.
this study demonstrates the role of NCR1 in antibody response to mouse cytomegalovirus infection
Our findings uncover a detrimental role of T-bet-dependent NKp46(+) ILCs in the development of CNS autoimmune disease.
The results identify an unexpected phenotypic instability within NKp46(+) ILC3 that suggests a major role for environmental signals in tuning ILC3 functional plasticity.
The authors delineated the fungal ligands to be the Candida glabrata adhesins Epa1, Epa6, and Epa7 and demonstrated that clearance of systemic Candida glabrata infections in vivo depends on their recognition by mouse NCR1.
it is demonstrated that NCR1 dampens allergic eosinophilic airway inflammation.
this study using Ncr1-deficient mice, shows that NCR1 plays a critical role in controlling human metapneumovirus infection
Rag knockout mice that possess fully functional NKp46(+) cells
NK cell receptor NKp46 regulates graft-versus-host disease.
Ifnar1(-/-) T cells had elevated expression of natural cytotoxicity triggering receptor 1 (NCR1) ligands upon infection, rendering them targets for NCR1 mediated NK cell attack.
Data from knockout/transgenic mice suggest that activation of Ncr1 by endogenous (as yet undefined) ligands contributes to activation/maturation of uterine natural killer cells and likely makes critical contributions to implantation/placentation.
Here, we demonstrate the regulation of T-cell mediated allergic responses, which is dependent on the NK-cell specific receptor NKp46 (Ncr1 in mice).
NKp46 deficiency alone, or in combination with NKG2D deficiency, had no effect on frequency or function of NK cells
NCR1 and NKp46 directly recognize a periodontal pathogen.
NKp46/NCR1 plays an important role in controlling neoplasm metastasis
downregulation of NK activity by NKp46 associated with silencing of Helios in NK cells; NKp46 critical for development of antiviral and antibacterial T cell response
Fate mapping experiments demonstrated the stable expression of NKp46 on NK cells and allowed a reappraisal of the sequential steps of NK cell maturation
these data indicate that NKp46 is not expressed by all porcine NK cells and that NKp46 discriminates porcine NK cells differing in regard to cytokine production, which challenges the paradigm of NKp46 as a comprehensive marker for NK cells across different mammalian species.
has similarity to immunoglobulins\; expressed in NK cells
NK cell-activating receptor
, lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46)
, natural killer cell p46-related protein
, MAR1 (mouse activating receptor 1)
, activating receptor 1
, lymphocyte antigen 94
, NK receptor KILR-1
, lymphocyte antigen 94 homolog (activating NK-receptor
, rat-activating receptor 1