Browse our SH2 Domain Containing 1A Proteins (SH2D1A)

Human SH2 Domain Containing 1A (SH2D1A) interaction partners

1. these results showed that the NTB-A (show SLAMF6 Proteins)/SAP (show APCS Proteins) pathway regulates T-cell activation and restimulation-induced cell death during human tuberculosis

2. this paper shows that the X-linked lymphoproliferative disease gene product SAP (show APCS Proteins) regulates signals induced through the co-receptor SLAM (show SLAMF1 Proteins)

3. we describe for the first time the clinical manifestations associated with XLP-1 based on the c.278G>A variant in the SH2D1A gene. The patient had a relatively late age of onset and presented mainly with primary HLH associated with EBV infection without a familial history of immunodeficiency.

4. this study shows reduced intracellular SAP (show APCS Proteins) expression in iNKT cells and other lymphocytes in the blood from common variable immunodeficiency

5. in X-linked lymphoproliferative disease patient (show APCS Proteins)s, SAP deficiency reduces CD74 expression, resulting in the perturbation of B cell maintenance from the naive stage

6. study concludes that systemic lupus erythematosus (SLE) T cells display reduced levels of the adaptor protein SAP (show APCS Proteins), probably as a result of continuous T cell activation and degradation by caspase-3 (show CASP3 Proteins). Restoration of SAP (show APCS Proteins) levels in SLE T cells corrects the overexcitable lupus T cell phenotype.

7. High LAT1 expression correlated with significantly shorter prostate specific antigen recurrence-free survival in patients receiving androgen deprivation therapy

8. We describe here a novel c.137+5G > A intronic mutation in the SH2D1A gene of the signaling lymphocyte activation molecule (SLAM (show SLAMF1 Proteins))-associated protein (SAP) in association with Epstein-Barr virus (EBV)-induced fatal infectious mononucleosis (FIM) in an 8-year-old male patient and his 3-year-old step brother. The mother and the maternal grandmother of the boys are healthy and heterozygous for this sequence variant.

9. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

10. The mutation c.131G>A in this patient was found in combination with a second SH2D1A mutation

Mouse (Murine) SH2 Domain Containing 1A (SH2D1A) interaction partners

1. naive T cells regulate B cell survival in a SAP (show APCS Proteins)-dependent manner

2. SAP (show APCS Proteins)-dependent activating SFR signaling is essential for NKT (show CTSL1 Proteins) cell selection.

3. SAP (show APCS Proteins) differentially regulates the late-stage lineage decisions of iNKT cell subsets. These results also provide evidence that iNKT1, iNKT2, and iNKT17 cells are differentially regulated by SAP (show APCS Proteins). SAP (show APCS Proteins)-dependent signals are essential for the fate decisions that drive the differentiation of iNKT2 but not iNKT1 and NKT17 cells.

4. SAP (show APCS Proteins) is an essential molecule for autoimmune antibody production.

5. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

6. SLAM (show SLAMF1 Proteins)-SAP (show APCS Proteins) signaling promotes differentiation of IL-17 (show IL17A Proteins)-producing T cells and progression of experimental autoimmune encephalomyelitis.

7. these data suggest that SAP (show APCS Proteins) is critical for regulating type II NKT (show CTSL1 Proteins) cell responses.

8. functional analysis in vitro indicates that SAP-2 is a non-functional isoform due to decreased protein stability

9. Here we report that B cell intrinsic responses to haptenated protein antigens are impaired in SAP (show APCS Proteins)-/- mice and in Rag-/- mice into which B cells derived from SAP (show APCS Proteins)-/- mice together with wt CD4 (show CD4 Proteins)+ T cells had been transferred.

10. SAP (show APCS Proteins) plays an essential role in CIA (show NCOA5 Proteins) because of Fyn (show FYN Proteins)-independent and Fyn (show FYN Proteins)-dependent effects on TFH cells and, possibly, other T cell types.