Browse our anti-CREM (CREM) Antibodies

Human CAMP Responsive Element Modulator (CREM) interaction partners

1. We describe a novel gene fusion, EWSR1-CREM, identified in 3 cases of clear cell carcinoma

2. EWSR1 fusion with CREM has only been observed in 3 intracranial myxoid tumors

3. Genetic studies in seven independent human populations illustrate that a CREM promoter variant at rs12765063 is associated with impulsivity, hyperactivity and addiction-related phenotypes.

4. Increased CREM expression is also observed in early E. histolytica infection

5. CREM drives an inflammatory phenotype of T cells in Juvenile idiopathic arthritis.

6. this study shows an eventually involvement of CREM gene in the development of T1D pathology in Tunisian families. These facts are consistent with a major role for transcription factor genes involved in the immune pathways in the control of autoimmunity.

7. Data indicate a role for inducible cyclic AMP early repressor (ICER) in G1 checkpoint regulation in hematopoietic stem cells (HSCs).

8. Report a distinct group of myxoid mesenchymal neoplasms occurring in children or young adults with a predilection for intracranial locations with EWSR1-AFT1/CREB1/CREM fusions.

9. Study provides evidence that increased Set1 binding at the promoter induces aberrant epigenetic alterations and up-regulates CREMA in systemic lupus erythematosus.

10. CREMalpha SNPs rs2295415 and rs1057108 may be novel genetic susceptibility factors for SLE, especially at haplotype level.

11. These findings indicated that the polymorphisms of CREM gene were associated with nonobstructive azoospermia in the Chinese population and low CREM expression might be involved in the pathogenesis of spermatogenesis maturation arrest.

12. overexpressed in the nuclei of hepatocellular carcinoma cells

13. In Alzheimer's brain, we found an increased cellular expression of CREM in dentate gyrus neurons as compared to normal aging brains.

14. Data suggest ICER/CREM plays seminal role in down-regulation of expression/secretion of insulin by pancreatic beta-cell as an adaptive response to factors that promote diabetes; inappropriate induction of ICER leads to beta-cell dysfunction. [REVIEW]

15. CaMK4-dependent activation of AKT/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance.

16. CREMalpha orchestrates epigenetic remodeling of the CD8A,B through the recruitment of DNA methyltransferase (DNMT) 3a and histone methyltransferase G9a.

17. Data suggest that cyclic AMP response element modulator-1 (CREM-1) might play an important role in the regulation of tumor metastasis and invasion and serve as a tumor suppressor in esophageal squamous cell carcinoma (ESCC).

18. Transcription factor CREM is an important regulator of atrial growth implicated in the development of atrial fibrillation.

19. transcription factor cAMP-responsive element modulator alpha (CREMalpha), which is expressed at increased levels in T cells from systemic lupus erythematosus patients, contributes to transcriptional silencing of CD8A and CD8B.

20. The results of this study suggested that the single nucleotide polymorphisms of CREM do not influence diagnosis and treatment response in patients with major depressive disorder and bipolar disorder.

Cow (Bovine) CAMP Responsive Element Modulator (CREM) interaction partners

1. results are consistent with the suggestions that cAMP responsive element modulator variants are involved in spermiogenesis in the testes of Japanese Black bulls

Mouse (Murine) CAMP Responsive Element Modulator (CREM) interaction partners

1. CREM-/- mice were more susceptible to E. histolytica amebic colitis

2. Studied role and importance of inducible cAMP early repressor (ICER) in glutaminolysis and the generation of Th17 cells. Demonstrated the IL-17 promoting ICER works through the direct control of glutaminase 1 (Gls1) by binding its promoter.

3. Deficiency in ICER elevated binding of NF-kappaB to promoters of pro-inflammatory genes and their subsequent gene expression. Mice deficient in ICER were hypersensitive to LPS-induced endotoxic shock and showed propagated inflammation.

4. The transcription factor CREM was found to be important in the regulation of cardiotoxicity-associated genes.

5. Our results demonstrate that overexpression of CREMalpha in T cells changes the inflammatory milieu, attenuating initiation and progression of CLD.

6. the role of ICER in ovarian function, was investigated.

7. Phosphorylated Tssk4 might participate in testis genes expressions by phosphorylating Crem at Ser-117.

8. the signaling pathways mediating GnRH activation of CREB and ICER are distinct, contributing to the decoding of the pulsatile GnRH to regulate FSHbeta expression.

9. Crem(-/-) mice exhibited increased proliferation of primary aortic VSMCs along with upregulation of PDGF signaling.

10. overexpressed in the nuclei of hepatocellular carcinoma cells

11. Unlike in T cells from spleen, CREMalpha overexpression did not induce a predominant Th17 response in intrahepatic T cells

12. These data identify ICER as a redundant mediator of Treg cells and cAMP action on Teff cells and suggest that Epac may function as an alternative effector to promote cAMP-dependent Teff cell suppression.

13. CaMK4-dependent activation of AKT/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance.

14. CREMalpha orchestrates epigenetic remodeling of the CD8A,B through the recruitment of DNA methyltransferase (DNMT) 3a and histone methyltransferase G9a.

15. The results of this study suggested that activation of CREMtau may provide a means to accelerate the therapeutic efficacy of current antidepressant treatment.

16. levels of CREM in T cells determine the outcome of acute lung injury, and CREMalpha transgenic animals represent a model in which proinflammatory T cells aggravate acute lung injury in different phases of the disease.

17. Reduction of connexin36 content by ICER-1 contributes to insulin-secreting cells apoptosis induced by oxidized LDL particles.

18. Inducible cAMP early repressor regulates the Period 1 gene of the hepatic and adrenal clocks.

19. Data suggest that expression of TRH (thyrotropin-releasing hormone) is up-regulated by CREM in hypothalamus; however, regulation of TRH by triiodothyronine appears independent of expression of CREM or CREB (cAMP responsive element binding protein).

20. analysis of insights into the downstream pathways and targets controlled by transcription factors CREM in the testis