RHEB Products
(Ras Homolog Enriched in Brain (RHEB))
Categories
This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008].
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Featured RHEB Categories
RHEB Antibodies
High quality antibodies with extensive validation data.
RHEB Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RHEB Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (6)
Cat. No.
ABIN519784
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7154592
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (2)
Cat. No.
ABIN704771
Quantity
100 μL
Datasheet
Datasheet
Recommended RHEB ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6951226
Quantity
96 tests
Datasheet
Datasheet
Recommended RHEB Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124780
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN666866
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317998
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our RHEB products
: "RHEB: a potential regulator of chondrocyte phenotype for cartilage tissue regeneration." in: Journal of tissue engineering and regenerative medicine, (2016) (PubMed).: "In vivo AAV1 transduction with hRheb(S16H) protects hippocampal neurons by BDNF production." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 23, Issue 3, pp. 445-55, (2015) (PubMed).
: "Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome." in: Cell, Vol. 156, Issue 4, pp. 771-85, (2014) (PubMed).
: "Formation of endothelial lumens requires a coordinated PKCepsilon-, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation." in: Journal of cell science, Vol. 122, Issue Pt 11, pp. 1812-22, (2009) (PubMed).
: "Phospholipase D1 is an effector of Rheb in the mTOR pathway." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 24, pp. 8286-91, (2008) (PubMed).
: "Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38." in: Science (New York, N.Y.), Vol. 318, Issue 5852, pp. 977-80, (2007) (PubMed).
: "Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling." in: Genes & development, Vol. 17, Issue 15, pp. 1829-34, (2003) (PubMed).
: "Rheb is an essential regulator of S6K in controlling cell growth in Drosophila." in: Nature cell biology, Vol. 5, Issue 6, pp. 559-65, (2003) (PubMed).
: "Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins." in: Nature cell biology, Vol. 5, Issue 6, pp. 578-81, (2003) (PubMed).
: "Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals." in: Molecular and cellular biology, Vol. 17, Issue 2, pp. 921-33, (1997) (PubMed).
Synonyms and alternative names related to RHEB
Ras homolog, mTORC1 binding (RHEB), Ras homolog enriched in brain (Rheb), Ras homolog, mTORC1 binding (Rheb), Ras homolog enriched in brain (RHEB), Ras homolog, mTORC1 binding (rheb), ras homolog enriched in brain (rheb), Ras homolog, mTORC1 binding L homeolog (rheb.L), CG1081, Dmel\CG1081, Dm Rheb, DmRheb, DReb, dRheb, Q9VND8, RHEB, RheB, rheb, RHEB2, rheb2Protein level used designations for RHEB
- GTP-binding protein Rheb
- Ras homolog enriched in brain 2
- RAS-homolog enriched in brain
- Ras homolog enriched in brain
- ras homolog enriched in brain
- GTP-binding protein rheb
- CG1081 gene product from transcript CG1081-RA
- CG1081-PA
- CG1081-PB
- RAS homolog enriched in brain
- Ras homolog enriched in brain ortholog
- Ras homologue enriched in brain
- Ras homology enriched in brain
- Rheb-PA
- Rheb-PB
- Ras homolog enriched in brain L homeolog
- Ras homolog, mTORC1 binding L homeolog
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