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anti-Human CELF4 Antibodies:
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Human Polyclonal CELF4 Primary Antibody for ICC, IF - ABIN4285429
Wagnon, Briese, Sun, Mahaffey, Curk, Rot, Ule, Frankel: CELF4 regulates translation and local abundance of a vast set of mRNAs, including genes associated with regulation of synaptic function. in PLoS genetics 2012
Show all 2 Pubmed References
Cow (Bovine) Polyclonal CELF4 Primary Antibody for WB - ABIN2779151
Szafranski, Schindler, Taudien, Hiller, Huse, Jahn, Schreiber, Backofen, Platzer: Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. in Genome biology 2008
The present study refines the molecular and neuropsychiatric phenotype associated with 18q12.2 deletion leading to CELF4 haploinsufficiency and provides evidence for a role for CELF4 in brain development and autism spectrum disorders.
Authors report a modifying effect of a polymorphism of CELF4 on the dose-dependent association between anthracyclines and cardiomyopathy, which possibly occurs through a pathway that involves the expression of abnormally spliced TNNT2 variants.
Determination of CELF4 protein domains required for RNA splicing.
validated occurrence of an unusual TG 3' splice site in intron 6
Celf4 might be regulating alternative early in retinal development.
we suggest that CELF4 deficiency leads to abnormal neuronal function by combining a specific effect on neuronal excitation with a general impairment of synaptic transmission.
Data point strongly to the conclusion that Celf4 deletion primarily from excitatory neurons promotes convulsive seizure phenotypes.
cloning and characterization
CELF protein activity is required for normal alternative splicing in the heart in vivo and normal CELF-mediated alternative splicing regulation is in turn required for normal cardiac function.
Brunol4 deficiency in mice results in a complex seizure phenotype, likely due to the coordinate dysregulation of several molecules, providing a unique new animal model of epilepsy
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple transcript variants encoding different isoforms have been found for this gene.
, CUG-BP- and ETR-3-like factor 4
, CUGBP Elav-like family member 4
, RNA-binding protein BRUNOL-4
, bruno-like protein 4
, RNA binding protein Bruno-like 4
, Bruno -like 4, RNA binding protein
, CUG-BP and ETR-3 like factor 4
, LYST-interacting protein LIP9
, RNA-binding protein BRUNOL4
, bruno-like 4, RNA binding protein
, CUG-BP and ETR-3-like factor 4