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anti-Mouse (Murine) DDR1 Antibodies:
anti-Human DDR1 Antibodies:
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Human Monoclonal DDR1 Primary Antibody for ELISA, WB - ABIN965982
Foehr, Tatavos, Tanabe, Raffioni, Goetz, Dimarco, De Luca, Bradshaw: Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000
Show all 4 Pubmed References
Human Monoclonal DDR1 Primary Antibody for ELISA, WB - ABIN969082
Mohan, Mohan, Wilson: Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea. in Experimental eye research 2001
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Human Polyclonal DDR1 Primary Antibody for ELISA, WB - ABIN560139
Turashvili, Bouchal, Baumforth, Wei, Dziechciarkova, Ehrmann, Klein, Fridman, Skarda, Srovnal, Hajduch, Murray, Kolar: Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis. in BMC cancer 2007
Human Polyclonal DDR1 Primary Antibody for IHC (p) - ABIN2478753
Coakley, Hawkins, Crinis, McManus, Blake, Nordmann, Sloan, Connelly: An unusual case of variegate porphyria with possible homozygous inheritance. in Australian and New Zealand journal of medicine 1990
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Human Polyclonal DDR1 Primary Antibody for IHC, ELISA - ABIN1847697
Xu, Abe, Liu, Zalivina, Hohenester, Leitinger: Normal activation of discoidin domain receptor 1 mutants with disulfide cross-links, insertions, or deletions in the extracellular juxtamembrane region: mechanistic implications. in The Journal of biological chemistry 2014
DDR1 kinase activity is required for regulating collagen IV (show COL4 Antibodies) synthesis.
DDR-1 interacts with the TGF-beta (show TGFB1 Antibodies) pathway to restrict calcifying extracellular vesicle-mediated mineralization and fibrosis by smooth muscle cells.
alpha5(IV), but not alpha1(IV), promotes lung cancer cell proliferation and tumor angiogenesis through non-integrin collagen receptor (show ITGA2 Antibodies) DDR1-mediated ERK (show EPHB2 Antibodies) activation.
DDR1 malfunction causes outer hair cells deformation and the separation of the lateral wall, the location of the cellular motor responsible for the electromotile property, explicitly in those regions showing DDR1 and NM-IIA co-localization.
the collagen receptors DDR1 and integrin a2b1 contribute to regulate GBM-maturation and to control matrix accumulation.
Extensive co-localization and relationship of Jag1 (show JAG1 Antibodies) and Ddr1 in bile ducts and blood vessels in postnatal liver.
Genetic inhibition of discoidin domain receptor 1 protects mice against crescentic glomerulonephritis.
Data identifyies Syk (show SYK Antibodies) as a potent inhibitor of epithelial migration and describes a first functional consequence of the interaction with the collagen receptor (show ITGA2 Antibodies) DDR1.
Results show that DDR1 promotes cell-cell adhesion and differentiation through stabilization of E-cadherin (show CDH1 Antibodies), which is mediated by Cdc42 (show CDC42 Antibodies) inactivation.
Collagen I stimulates the self-renewal of embryonic stem cells mediated by Bmi-1 (show BMI1 Antibodies) through alpha2beta1 integrin-dependent ILK (show ILK Antibodies), Notch (show NOTCH1 Antibodies), Gli-1 (show GLI1 Antibodies), and DDR1-dependent Ras, PI3K/Akt (show AKT1 Antibodies), and ERK (show EPHB2 Antibodies).
These results support an activation mechanism of DDR1 whereby collagen induces lateral association of DDR1 dimers and phosphorylation between dimers.
Data suggest that IGF-I (show IGF1 Antibodies)/IGF-IR system triggers stimulatory actions through both GPER (show GPER Antibodies) and DDR1 in aggressive tumors as mesothelioma and lung tumors.
we further analyzed the CpG methylation levels at the DDR1 promoter in EOC cells and found that the CpG methylation levels of DDR1 promoter correlated negatively with the expression of DDR1 along the EMT (show ITK Antibodies) spectrum. Therefore, EMT (show ITK Antibodies) stratification could be a potential biomarker to predict patient response to DDR1-targeting drugs.
This study suggested that DDR1 and DDR2 (show DDR2 Antibodies) knockdown alters brain immunity and significantly reduces the level of triggering receptor expressed on myeloid cells (TREM)-2 (show TREM2 Antibodies) and microglia.
Isoform b of DDR1 is responsible for collagen I-induced up-regulation of N-cadherin (show CDH2 Antibodies) and tyrosine 513 of DDR1b is necessary.
Reduced DDR1 expression may be implicated in impaired melanocyte adhesion process involved in vitiligo (show MITF Antibodies) pathogenesis
data demonstrate that TGF-beta1 (show TGFB1 Antibodies) favors linear invadosome formation through the expressions of both the inducers, such as collagen and LOXL2 (show LOXL2 Antibodies), and the components such as DDR1 and MT1-MMP (show MMP14 Antibodies) of linear invadosomes in cancer cells. Meanwhile, our data uncover a new TGF-beta1 (show TGFB1 Antibodies)-dependent regulation of DDR1 expression.
DDR1 overexpression promoted GC cell proliferation (p < 0.05), migration (p < 0.01), and invasion (p < 0.01), and accelerated the growth (p < 0.05) as well as the microvessel formation (p < 0.01) of transplantation tumor in nude mice.
Our results suggest that DDR1 is both a prognostic marker for renal clear cell carcinoma and a potential functional target for therapy
Study concludes that non-canonical DDR1 signaling enables breast cancer cells to exploit the ubiquitous interstitial matrix component collagen I to undergo metastatic reactivation in multiple target organs.
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, discoidin domain receptor
, CD167 antigen-like family member A
, cell adhesion kinase
, discoidin receptor tyrosine kinase
, epithelial discoidin domain receptor 1
, epithelial discoidin domain-containing receptor 1
, protein-tyrosine kinase MPK-6
, tyrosine kinase DDR
, tyrosine-protein kinase CAK
, PTK3A protein tyrosine kinase 3A
, mammary carcinoma kinase 10
, neuroepithelial tyrosine kinase
, neurotrophic tyrosine kinase, receptor, type 4
, protein-tyrosine kinase RTK-6
, discoidin domain receptor family, member 1
, neurotrophic tyrosine kinase receptor type 4
, protein-tyrosine kinase 3
, protein-tyrosine kinase PTK-3