DDR1 antibody (AA 299-330)

Catalog No. ABIN391458

The Rabbit Polyclonal anti-DDR1 antibody (Clone RB14442) (ABIN391458) specifically detects DDR1 in WB, FACS, IHC (p) and IF. The antibody is reactive with Human samples.

Quick Overview for DDR1 antibody (AA 299-330) (ABIN391458)

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDR1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Clone: RB14442

Product Details anti-DDR1 Antibody

Binding Specificity: AA 299-330

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DDR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-330 amino acids from the Central region of human DDR1.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:500. IHC-P: 1:100. IHC-P: 1:100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for DDR1

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Alternative Name: DDR1

Background: Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. DDR1 is an RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. It belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis show that expression of DDR1 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain.

Molecular Weight: 101128

Gene ID: 780

NCBI Accession: NP_001189450, NP_001189451, NP_001189452, NP_001945, NP_054699, NP_054700

UniProt: Q08345

Pathways: RTK Signaling, Smooth Muscle Cell Migration