DDR1 antibody (AA 396-430)

Catalog No. ABIN6243407

This Rabbit Polyclonal antibody specifically detects DDR1 in WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for DDR1 antibody (AA 396-430) (ABIN6243407)

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDR1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB50593

Product Details anti-DDR1 Antibody

Binding Specificity: AA 396-430

Predicted Reactivity: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Ddr1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 396-430 amino acids from the Central region of human Mouse Ddr1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for DDR1

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Alternative Name: Ddr1

Background: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tumor cell invasion. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Phosphorylates PTPN11 (By similarity). Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing.

Molecular Weight: 101161

UniProt: Q03146

Pathways: RTK Signaling, Smooth Muscle Cell Migration