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anti-Mouse (Murine) GRB2 Antibodies:
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Chicken Monoclonal GRB2 Primary Antibody for BI, IP - ABIN967755
Elowe, Holland, Kulkarni, Pawson: Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction. in Molecular and cellular biology 2001
Show all 5 Pubmed References
Chicken Monoclonal GRB2 Primary Antibody for BI, IP - ABIN967754
Miki, Miura, Matuoka, Nakata, Hirokawa, Orita, Kaibuchi, Takai, Takenawa: Association of Ash/Grb-2 with dynamin through the Src homology 3 domain. in The Journal of biological chemistry 1994
Show all 5 Pubmed References
Human Polyclonal GRB2 Primary Antibody for ELISA, IHC - ABIN257708
Lowenstein, Daly, Batzer, Li, Margolis, Lammers, Ullrich, Skolnik, Bar-Sagi, Schlessinger: The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. in Cell 1992
Human Polyclonal GRB2 Primary Antibody for IHC (p), WB - ABIN390236
Kondo, Hirayama, Sugito, Shono, Tanaka, Kitamura: Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation. in The Journal of biological chemistry 2008
Show all 3 Pubmed References
Our findings position Grb2 as a key adaptor that integrates various cytokines response in cycling Hematopoietic Stem and Progenitor Cell .
Themis1 acts as a positive regulator of TCR signaling during thymocyte development by promoting Vav1 (show VAV1 Antibodies) activity and Grb2 stability
Myogenic differentiation depends on the expression regulation patterns of Grb2 and N-WASP.
Two Dtna (show DTNA Antibodies) interactors, alpha-catulin (show CTNNAL1 Antibodies) (phosphorylation independent) and Grb2 (phosphorylation dependent) are localized to neuromuscular junctions in vivo, and are required for proper organization of neurotransmitter receptors on myotubes.
Grb2-deficient T cells show defects in T cell development, increased Th1 (show HAND1 Antibodies) and Th17 cell differentiation capacities, and impaired proliferation after activation by dendritic cells, which likely reduce the clinical symptoms of EAE.
provide evidence that CD28 (show CD28 Antibodies) and the TCR complex regulate NF-kappaB (show NFKB1 Antibodies) via different signaling modules of GRB-2/VAV1 (show VAV1 Antibodies) and LAT (show LAT Antibodies)/ADAP (show APP Antibodies) pathways respectively.
GRB2 physically links cyt (show CYGB Antibodies)-PTPe (show PTPRE Antibodies) with Src (show SRC Antibodies) and enables cyt (show CYGB Antibodies)-PTPe (show PTPRE Antibodies) to activate Src (show SRC Antibodies) downstream of activated integrins in osteoclast-like cells.
SUMOylation of Grb2 enhances the ERK (show EPHB2 Antibodies) activity by increasing its binding with Sos1 (show SOS1 Antibodies).
Data indicate that growth factor receptor (show RYK Antibodies) protein binding protein 2 (Grb2) is upregulated and regulated by Forkhead Box D3 (Foxd3 (show FOXD3 Antibodies)), and pregulated Grb2 interacts with huntingtin (Htt (show HTT Antibodies)).
Grb2 contributes to immunoreceptor tyrosine-based activation motif signaling in platelets during hemostasis and thrombosis.
Data indicate GRB2 as a direct target of miR (show MLXIP Antibodies)-329 in pancreatic cancer cells, and expression of GRB2 was inversely correlated with miR (show MLXIP Antibodies)-329 expression in pancreatic cancer patients.
EGFR (show EGFR Antibodies) colocalization with GRB2 as assessed by PLA is not correlated with EGFR (show EGFR Antibodies) expression levels or mutation status, defining a patient group that may show EGFR (show EGFR Antibodies) pathway activation, as illustrated by its prognostic value.
Low GRB2 expression is associated with Breast Cancer.
Rab13 (show RAB13 Antibodies) activated the downstream AMPK (show PRKAA1 Antibodies) and blocked mTOR (show FRAP1 Antibodies) signaling by its functional interaction with Grb2 to regulate autophagy in human vascular endothelial cells.
ACTB (show ACTB Antibodies), CDKN1B (show CDKN1B Antibodies), GAPDH (show GAPDH Antibodies), GRB2, RHOA (show RHOA Antibodies) and SDCBP (show SDCBP Antibodies) are potent reference genes in neuroendocrine tumors of the lung.
We show that the decrease in PI(4,5)P2 level under non-stimulated conditions inhibits PTEN (show PTEN Antibodies) activity leading to the aberrant activation of the oncoprotein Akt (show AKT1 Antibodies). As well as defining a novel mechanism of Akt (show AKT1 Antibodies) phosphorylation with important therapeutic consequences, we also demonstrate that differential expression levels of FGFR2 (show FGFR2 Antibodies), Plc11 and Grb2 correlate with patient survival
Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2), Grb2-related adaptor downstream of Shc (show SHC1 Antibodies) (Gads (show GRAP2 Antibodies)), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src (show SRC Antibodies) homology 2 (SH2) domains, leading to downstream signaling to distinct immune pathways. These three adaptor proteins bind to the same site on CD28 (show CD28 Antibodies) with variable affinity
investigated the target and mechanism of miR-411-5p in breast cancer using mimic and inhibitor, and demonstrated the involvement of GRB2 and Ras activation
The study presents EPR (show EREG Antibodies) spectroscopic analysis of the binding of the wild-type and mutant Grb2 SH2 domains to the CSpYVNVQC peptide variant. These data confirm that the binding specificity of SH2 domains, even that of Grb2, results from multiple factors and does not depend merely on the nature of one particular residue.
TGF-beta2 (show TGFB2 Antibodies) induces Grb2 to recruit PI3-K (show PIK3CA Antibodies) to TGF-RII that activates JNK (show MAPK8 Antibodies)/AP-1 (show FOSB Antibodies)-signaling and augments invasiveness of Theileria-transformed macrophages.
in VSMCs exposed to hyperglycemia, IGF-I (show IGF1 Antibodies) stimulation of Shc (show SHC1 Antibodies) facilitates the transfer of Grb2 to p85 (show ARHGEF7 Antibodies) resulting in enhanced PI3K activation and AKT (show AKT1 Antibodies) phosphorylation leading to enhanced cell proliferation and migration
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
growth factor receptor-bound protein 2
, Growth factor receptor-bound protein 2
, SH2/SH3 adapter GRB2
, adapter protein GRB2
, protein Ash
, abundant SRC homology
, epidermal growth factor receptor-binding protein GRB2
, growth factor receptor-bound protein 3
, growth factor receptor bound protein 2