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Sck was identified as a novel molecule indispensable for CD95 (show FAS Proteins)'s activation of the PI3K (show PIK3CA Proteins) and MAPK (show MAPK1 Proteins) pathways and induction of cell cycle progression in pancreatic ductal adenocarcinoma.
SHC2 gene deletions underlie few, if any, cases of well-characterized multiple system atrophy in the US population.
Data show that copy number loss of SHC2 strongly indicates a causal link to multiple system atrophy.
predicted to be a member of the Shc family of adaptor proteins that bind to receptor tyrosine kinases and mediate cell signalling
SH2 domain protein C2
, SHC-transforming protein 2
, SHC-transforming protein B
, neuronal Shc adaptor homolog
, protein Sck
, src homology 2 domain-containing-transforming protein C2
, protein Sli
, src homology 2 domain-containing transforming protein C2