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anti-Human TYRO3 Antibodies:
anti-Rat (Rattus) TYRO3 Antibodies:
anti-Mouse (Murine) TYRO3 Antibodies:
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Mouse (Murine) Monoclonal TYRO3 Primary Antibody for CyTOF, ELISA (Capture) - ABIN4900191
Fujimori, Grabiec, Kaur, Bell, Fujino, Cook, Svedberg, MacDonald, Maciewicz, Singh, Hussell: The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung. in Mucosal immunology 2015
Show all 4 Pubmed References
Human Monoclonal TYRO3 Primary Antibody for FACS - ABIN4897539
Gould, Baxi, Schroeder, Peng, Leadley, Peterson, Perrin: Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses. in Journal of thrombosis and haemostasis : JTH 2005
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Human Monoclonal TYRO3 Primary Antibody for IF, ELISA - ABIN967221
Janssen, Schulz, Steenvoorden, Schmidberger, Strehl, Ambros, Bartram: A novel putative tyrosine kinase receptor with oncogenic potential. in Oncogene 1991
Show all 3 Pubmed References
Human Monoclonal TYRO3 Primary Antibody for ELISA, WB - ABIN969449
Lan, Wu, Li, Wu, Lu, Xu, Dai: Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway. in Blood 2000
Human Monoclonal TYRO3 Primary Antibody for ICC, ELISA - ABIN1724702
Hafizi, Gustafsson, Stenhoff, Dahlbäck: The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases. in The international journal of biochemistry & cell biology 2005
Mouse (Murine) Monoclonal TYRO3 Primary Antibody for FACS - ABIN4897330
Taichman, Patel, Bedenis, Wang, Weidner, Schumann, Yumoto, Berry, Shiozawa, Pienta: GAS6 receptor status is associated with dormancy and bone metastatic tumor formation. in PLoS ONE 2013
Human Polyclonal TYRO3 Primary Antibody for FACS, ICC - ABIN440474
Chan, Carrera Silva, De Kouchkovsky, Joannas, Hao, Hu, Huntsman, Eng, Licona-Limón, Weinstein, Herbert, Craft, Flavell, Repetto, Correale, Burchard, Torgerson, Ghosh, Rothlin: The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. in Science (New York, N.Y.) 2016
Human Monoclonal TYRO3 Primary Antibody for ELISA, WB - ABIN967223
Heiring, Dahlbäck, Muller: Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family. in The Journal of biological chemistry 2004
Show all 2 Pubmed References
Human Polyclonal TYRO3 Primary Antibody for ELISA, IP - ABIN2747776
Uehara, Shacter: Auto-oxidation and oligomerization of protein S on the apoptotic cell surface is required for Mer tyrosine kinase-mediated phagocytosis of apoptotic cells. in Journal of immunology (Baltimore, Md. : 1950) 2008
Data suggest that TYRO3-mediated phosphorylation of ACTN4 (show ACTN4 Antibodies) is involved in invasiveness of melanoma cells; TYRO3-mediated phosphorylation of ACTN4 (show ACTN4 Antibodies) requires FAK (show PTK2 Antibodies) activation at tyrosine 397. (TYRO3 = TYRO3 protein tyrosine kinase; ACTN4 (show ACTN4 Antibodies) = actinin alpha 4 (show ACTN4 Antibodies); FAK (show PTK2 Antibodies) = focal adhesion kinase isoform FAK1 (show PTK2 Antibodies))
Phosphatidylserine mediated hyperactivation of TYRO3.TYRO3 promotes epithelial cell efferocytosis in a tyrosine kinase (show TXK Antibodies)-dependent manner.TYRO3 role in AKT (show AKT1 Antibodies)-dependent drug resistance.
Taken together, our data indicate that elevated plasma Gas6 (show GAS6 Antibodies) levels is associated with the severity of disease during HTNV infection in humans, suggesting that Gas6 (show GAS6 Antibodies) may play an important role by binding with Tyro3 on monocytes.
Study identified the Gas6 (show GAS6 Antibodies)/TAM (show CCNA1 Antibodies) receptor pathway with Tyro3 and Mer (show MERTK Antibodies) as novel targets in colorectal cancer.
These results show that TYRO3, AXL (show AXL Antibodies) and GAS6 (show GAS6 Antibodies) are expressed at higher levels in LMS and expression of its ligands correlates to a worse PFS in LMS patients.
Patients with macroalbuminuria diabetes had higher circulating levels of sMer and more urinary soluble Tyro3 and sMer than normoalbuminuric diabetics. Increased clearance of sTyro3 and sMer was associated with loss of tubular Tyro3 and Mer (show MERTK Antibodies) expression in diabetic nephropathy tissue. During in vitro diabetes, human kidney cells had down-regulation of Tyro3 and Mer (show MERTK Antibodies) mRNA and increased shedding of sTyro3 and sMer.
TYRO3 is overexpressed in the early stage of colon cancer development and aberrant expression of TYRO3 promotes tumorigenesis and induces EMT (show ITK Antibodies) through the regulation of SNAI1 (show SNAI1 Antibodies).
In this paper, we review the biology of the Gas6 (show GAS6 Antibodies)/Tyro3, Axl (show AXL Antibodies), and MerTK (show MERTK Antibodies)(collectively named TAM (show CCNA1 Antibodies) system)and the current evidence supporting its potential role in the pathogenesis of multiple sclerosis .
these data suggest that Tyro3 contributes significantly to tumor growth, aggressiveness and liver dysfunction
Tyro3 gene dosage modulates Mertk (show MERTK Antibodies)-associated retinal degeneration, provide strong evidence for a direct role for TYRO3 in RPE (show RPE Antibodies) phagocytosis, and suggest that an eQTL (show EQTN Antibodies) can modify a recessive Inherited photoreceptor degenerations.
Disinhibiation of Gas6 (show GAS6 Antibodies) binding to Tyro3 due to PGRN (show GRN Antibodies) reduction results in activation of PKCalpha (show PKCa Antibodies) via PLCgamma, inducing tau phosphorylation at Ser203, mislocalization of tau to dendritic spines, and spine loss.
shows that Tyro3 has prosurvival roles in the appetite regulatory circuitry and could also provide useful insights towards the development of interventions targeting detrimental weight loss
The findings of this study indicated the critical importance of Tyro3 in potentiating central nervous system myelination
This study mapped the autophosphorylation sites of murine Tyro3 to tyrosine 723 and 756, with K540 being required for its kinase activity.
Axl (show AXL Antibodies), Mertk (show MERTK Antibodies) and Tyro3 receptors are not required for Zika virus entry and infection.
genetic ablation of a receptor tyrosine kinase (show ERBB3 Antibodies) encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity.
These results suggest that TAM (show CCNA1 Antibodies) receptors support NSCs survival, proliferation and differentiation by regulating expression of neurotrophins, especially the nerve growth factor.
Optimal TAM (show CCNA1 Antibodies) signaling requires coincident TAM (show CCNA1 Antibodies) ligand engagement of both its receptor and the phospholipid phosphatidylserine regulating TAM (show CCNA1 Antibodies) receptor tyrosine kinases Tyro3, Axl (show AXL Antibodies), and Mer (show ERH Antibodies) and their ligands Gas6 (show GAS6 Antibodies) and Protein S.
These findings indicate that Tyro3 is a critical signal for synovial hyperplasia, osteoclast differentiation and bone erosion during arthritis.
The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses.
TYRO3 protein tyrosine kinase
, Tyrosine-protein kinase receptor TYRO3
, tyrosine-protein kinase receptor TYRO3
, developmental receptor tyrosine kinase
, tyrosine-protein kinase DTK
, tyrosine-protein kinase receptor TYRO3-like
, tyrosine-protein kinase RSE
, tyrosine-protein kinase SKY
, tyrosine-protein kinase TIF
, tyrosine-protein kinase byk
, Bruton agammaglobulinemia tyrosine kinase
, TYRO3 protein tyrosine kinase 3
, Axl-related receptor tyrosine kinase
, protein-tyrosine kinase
, retina-expressed kinase
, Xenopus kinase of Sky family
, tyrosine kinase