RVFV G Protein (His tag)
This Recombinant RVFV G protein is produced in Baculovirus infected Insect Cells.
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Quick Overview for RVFV G Protein (His tag) (ABIN7195956)
Target
RVFV G
(Rift Valley Fever Virus Glycoprotein (RVFV G))
Protein Type
Recombinant
Origin
Rift Valley Fever Virus (RVFV)
Source
Baculovirus infected Insect Cells
Purity
> 90 as determined by SDS-PAGE.
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Purification tag / Conjugate
- This RVFV G protein is labelled with His tag.
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Purpose
- Recombinant Rift Valley fever virus (RVFV) (strain MP12) glycoprotein / G2 Protein (His Tag)
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Sequence
- Cys691-Ser1139
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Characteristics
- A DNA sequence encoding the Rift Valley fever virus (RVFV) (strain MP12) Gc (ABD38821.1) (Cys691-Ser1139) was expressed with a polyhistidine tag at the N-terminus.
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Endotoxin Level
- < 1.0 EU per μg protein as determined by the LAL method.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile 20 mM Tris,150 mM NaCl, pH 8.0,10 % glycerol Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- RVFV G (Rift Valley Fever Virus Glycoprotein (RVFV G))
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Alternative Name
- RVFV-G
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Target Type
- Viral Protein
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Background
- Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. It is classified within the genus pneumovirus of the family paramyxoviridae. Like other members of the family, HRSV has two major surface glycoproteins (G and F) that play important roles in the initial stages of the infectious cycle. HRSV G protein is a type II glycoprotein of 289-299 amino acids (depending on the virus strain) with a signal/anchor hydrophobic domain and is extensively modified by the addition of both N-and O-linked oligosaccharides to achieve the mature form of 8-9 kDa. The C-terminal ectodomain of the G protein has a central region and four cysteines which are conserved in all HRSV isolates and have been proposed as the putative receptor binding site. The G protein mediates attachment of the virus to the host cell membrane by interacting with heparan sulfate, initiating the infection. As similar to mucins in amino acid compositions, the RSV G protein can interact with host CX3CR1, the receptor for the CX3C chemokine fractalkine, and thus modulates the immune response and facilitate infection. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors. Unlike the other paramyxovirus attachment proteins, HRSV-G lacks both neuraminidase and hemagglutinating activities.
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Molecular Weight
- 50.1kDa.
Target
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