Goat anti-Human IgA (Free & Bound), (Secretory Component) Antibody
ID, IP
Polyclonal
unconjugated
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- Target See all IgA products
- IgA
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Binding Specificity
- Free & Bound, Secretory Component
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Reactivity
- Human
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Host
- Goat
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Clonality
- Polyclonal
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Application
- Immunodiffusion (ID), Immunoprecipitation (IP)
- Purification
- Serum
- Immunogen
- Secretory component is present in human secretions bound to secretory IgA (sIgA) and in free form. Secretory IgA (sIgA) functions as a dimer or polymer and accounts for almost all specific mucosal antibody activity. A molecule of sIgA is made up of two molecules of IgA, one J chain and one SC (MW 65,000). The dimer IgA is transported into secretions by its binding to the SC on the epithelial cells. Under normal conditions, sIgA contains both subclasses IgA1 and IgA2, since both are capable of binding SC. SC also has an affinity for polymeric IgM. Purified free human secretory component isolated from pooled milk is used for immunization. Freund's complete adjuvant is used in the first step of the immunization procedure.
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Restore by adding 0.5 mLsterile distilled water. Dilutions may be prepared by adding PBS, pH 7.2
- Handling Advice
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Avoid repeated freezing and thawing.
Dilutions may be prepared by adding PBS, pH 7.2 - Storage
- 4 °C/-20 °C
- Storage Comment
- Prior to and following reconstitution store the antibody at 2-8 °C for one month or at -28 °C for longer.
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- Target
- IgA
- Abstract
- IgA Products
- Target Type
- Antibody
- Background
- Synonyms: Human Immunoglobulin A
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