Recombinant Rabbit anti-Human IgA (full length) Antibody

Catalog No. ABIN7878394

Quick Overview for Recombinant Rabbit anti-Human IgA (full length) Antibody (ABIN7878394)

Target: IgA

Antibody Type: Recombinant Antibody

Clonality: Monoclonal

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IGHA-3877R

Isotype: IgG

Product Details

Binding Specificity: full length

Reactivity: Human

Host: Rabbit

Purpose: Human IgA Antibody (Heavy chain)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human IGHA1 and IGHA2 proteins were used as the immunogen for the human IgA antibody.

Application Details

Application Notes: Optimal dilution of the human IgA antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the human IgA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details

Target: IgA

Target Type: Antibody

Background: This MAb is specific to heavy chain of IgA and shows minimal cross-reaction with heavy chains of other immunoglobulins. It is reactive with both IgA1 and IgA2 subclasses of Alpha heavy chain. It reacts with the third constant domain (CH3) of the alpha chain of IgA molecules. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through inter-chain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B-cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins.IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces.The most common feature of plasmacytomas, and certain non-Hodgkin s lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

UniProt: P01876