Recombinant Mouse anti-Human IgA (full length), (Heavy Chain) Antibody

Catalog No. ABIN7879398

Quick Overview for Recombinant Mouse anti-Human IgA (full length), (Heavy Chain) Antibody (ABIN7879398)

Target: IgA

Antibody Type: Recombinant Antibody

Clonality: Monoclonal

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RHISA43

Isotype: IgG1, kappa

Product Details

Binding Specificity: full length, Heavy Chain

Reactivity: Human

Host: Mouse

Purpose: Recombinant IgA Heavy Chain Antibody

Purification: Protein G affinity chromatography

Immunogen: Full length recombinant human IGHA protein was used as the immunogen for the human recombinant IgA Heavy Chain antibody.

Application Details

Application Notes: Optimal dilution of the recombinant IgA Heavy Chain antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant IgA Heavy Chain antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details

Target: IgA

Target Type: Antibody

Background: This MAb is specific to heavy chain of IgA and shows minimal cross-reaction with heavy chains of other immunoglobulins. It is reactive with all subclasses of Alpha heavy chain. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through inter-chain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B-cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins.IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces. The most common feature of plasmacytomas, and certain non-Hodgkins lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

UniProt: P01876