Mouse anti-Human IgA (Heavy Chain) Antibody (CF®488A)

Catalog No. ABIN7879448

Quick Overview for Mouse anti-Human IgA (Heavy Chain) Antibody (CF®488A) (ABIN7879448)

Target: IgA

Clonality: Monoclonal

Conjugate: CF®488A

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: IA761

Isotype: IgG1, kappa

Product Details

Binding Specificity: Heavy Chain

Reactivity: Human

Host: Mouse

Purpose: IgA Antibody

Purification: Protein G affinity chromatography

Immunogen: Purified human immunoglobulin alpha heavy chain was used as the immunogen for the Anti-IgA antibody.

Application Details

Application Notes: Optimal dilution of the IgA antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 500 µL at 0.1 mg/mL with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the IgA antibody at 2-8oC, protected from light.

Target Details

Target: IgA

Target Type: Antibody

Background: This MAb is specific to heavy chain of IgA and shows minimal cross-reaction with heavy chains of other immunoglobulins. It is reactive with all subclasses of Alpha heavy chain. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through inter-chain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B-cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins.IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces. The most common feature of plasmacytomas, and certain non-Hodgkin's lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

UniProt: P01876