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anti-Human IQGAP1 Antibodies:
anti-Rat (Rattus) IQGAP1 Antibodies:
anti-Mouse (Murine) IQGAP1 Antibodies:
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Human Polyclonal IQGAP1 Primary Antibody for IF (cc), IF (p) - ABIN737796
Fang, Zhang, Liu, Li, Zhou, Song, Zhao, Feng, Zhang, Li, Wen: PAX6 downregulates miR-124 expression to promote cell migration during embryonic stem cell differentiation. in Stem cells and development 2014
Human Polyclonal IQGAP1 Primary Antibody for ELISA, WB - ABIN4327480
Ren, Li, Sacks: IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling. in The Journal of biological chemistry 2008
Mouse (Murine) Polyclonal IQGAP1 Primary Antibody for ELISA, WB - ABIN314835
Bi, Mancias, Goldberg: Insights into COPII coat nucleation from the structure of Sec23.Sar1 complexed with the active fragment of Sec31. in Developmental cell 2007
Human Polyclonal IQGAP1 Primary Antibody for ICC, IF - ABIN438475
Sun, Kapuria, Peterson, Fang, Bornmann, Bartholomeusz, Talpaz, Donato: Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis. in Blood 2011
IQGAP1 plays an important role in the cell proliferation and invasion of human breast cancer cells.
These results show for the first time that IQGAP1 is up-regulated in Laryngeal squamous cell carcinoma (LSCC)tissues and plays an important role in LSCC cell proliferation and invasiveness, which indicates that IQGAP1 could work as an oncogene (show RAB1A Antibodies) and may serve as a promising molecular target for treatment of LSCC.
High IQGAP1 expression is associated with invasion in endometrial cancer.
Examined the expression of IQGAP1 in different pancreatic cancer cell lines and we found that IQGAP1 level is highly correlated with the degree of malignancy of pancreatic cancer cell metastasis. The proliferation, metastasis, motility and tumorigenesis in SW1990 human pancreatic cells were greatly impaired by down-regulating IQGAP1 expression with RNA interference.
Findings discover the IQGAP1 SUMOylation is a novel regulatory mechanism to enhance tumorigenesis and development of CRC (show CALR Antibodies) in vitro and in vivo.
IQGAP1 may have a role in podocyte gene regulation in glomerular disease.
When HEK293T cells were co-transfected with IQGAP1 and VCP (show vcp Antibodies), an immunoprecipitation assay revealed that binding of IQGAP1 with disease-related mutant (R155H or A232E) VCP (show vcp Antibodies) was markedly reduced compared to wild-type VCP (show vcp Antibodies). This suggests that reduction of IQGAP1 and VCP (show vcp Antibodies) interaction may be associated with the pathophysiology of inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD (show vcp Antibodies)).
the results show that IQGAP1 is a novel regulator of type I IFN production, possibly via interacting with NLRC3 (show NLRC3 Antibodies) in human monocytic and epithelial cells
The structural basis for Cdc42 (show CDC42 Antibodies)-induced dimerization of IQGAP1 and IQGAP2 (show IQGAP2 Antibodies) has been uncovered.
The LGR5 primarily functions via the IQGAP1-Rac1 pathway to strengthen cell-cell adhesion in normal adult crypt stem cells and colon cancer cells.
Alterations in IQGAP1 signalling promote the emergence of cancer stem cells and gastric adenocarcinoma development in the context of an H. pylori infection.
propose that the GRD and CT domains regulate IQGAP1 localization to retracting actin networks to promote a tumorigenic role in melanoma cells
Data highlight a unique mechanism of formin (show FMN1 Antibodies) action in which mDia1 and INF2 (show INF2 Antibodies) function in series to stabilize MTs (show NEU2 Antibodies) and point to IQGAP1 as a scaffold that facilitates the activation of one formin (show FMN1 Antibodies) by another.
Hectd1 (show HECTD1 Antibodies) regulates the protein level of IQGAP1 through ubiquitination.
Loss of IQGAP1 results in impaired insulin (show INS Antibodies) signaling and glucose homeostasis in vivo.
These data reveal that IQGAP1 binds to YAP (show YAP1 Antibodies) and modulates its co-transcriptional function, suggesting that IQGAP1 participates in Hippo signaling.
IQGAP1 has a strong signaling relationship with Ras genes in induction of cancer and it is considered as a key gene for induction or suppression of the hepatocellular carcinoma.
IQGAP1 has the potential to modulate airway contraction severity in acute asthma.
we propose that IQGAP1 acts as a small GTPase (show RACGAP1 Antibodies) scaffolding platform within the small GTPase (show RACGAP1 Antibodies) network, and recruits and/or regulates small GTPases, small GTPase (show RACGAP1 Antibodies) regulators and effectors to orchestrate cell behavior
This finding has new implications for involvement of IQGAP1 in cell polarization and migration events and potentially in cell cycle-associated nuclear envelope assembly/disassembly.
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.
RasGAP-like with IQ motifs
, ras GTPase-activating-like protein IQGAP1
, Cdc42-Rac1 effector protein