Browse our anti-LCK (LCK) Antibodies

Full name:: anti-Lymphocyte-Specific Protein tyrosine Kinase Antibodies (LCK)

On www.antibodies-online.com are 470 Lymphocyte-Specific Protein tyrosine Kinase (LCK) Antibodies from 36 different suppliers available. Additionally we are shipping LCK Kits (19) and LCK Proteins (15) and many more products for this protein. A total of 530 LCK products are currently listed.

Synonyms:: Hck-3, LCK, Lck1, Lcktkr, LSK, Lskt, p56, P56LCK, pp58lck, tkl, YT16, zgc:136695

list all antibodies	Gene Name	GeneID	UniProt
	LCK	16818	P06240
	LCK	3932	P06239
	LCK	313050	Q01621
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Most Popular Reactivities for anti-LCK (LCK) Antibodies

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anti-Mouse (Murine) LCK Antibodies:

anti-Human LCK Antibodies:

anti-Rat (Rattus) LCK Antibodies:

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Relevant Pathways for anti-LCK Antibodies

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Top referenced anti-LCK Antibodies

Human Monoclonal LCK Primary Antibody for IP, WB - ABIN967310 : Liu, Abraham: Subtractive cloning of a hybrid human endogenous retrovirus and calbindin gene in the prostate cell line PC3. in Cancer research 1991 (PubMed)
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Human Monoclonal LCK Primary Antibody for ICC, FACS - ABIN94422 : Romagnoli, Strahan, Pelosi, Cantagrel, van Meerwijk: A potential role for protein tyrosine kinase p56(lck) in rheumatoid arthritis synovial fluid T lymphocyte hyporesponsiveness. in International immunology 2001 (PubMed)
Show all 13 Pubmed References
Human Monoclonal LCK Primary Antibody for ICS - ABIN1176917 : Johnson, Bromley, Dustin, Thomas: A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation. in Proceedings of the National Academy of Sciences of the United States of America 2000 (PubMed)
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Human Monoclonal LCK Primary Antibody for ELISA, WB - ABIN969257 : Stachlewitz, Hart, Bettencourt, Kebede, Schwartz, Ratnofsky, Calderwood, Waegell, Hirst: A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection. in The Journal of pharmacology and experimental therapeutics 2005 (PubMed)
Show all 3 Pubmed References
Human Monoclonal LCK Primary Antibody for ICS - ABIN1177085 : Hardwick, Sefton: The activated form of the Lck tyrosine protein kinase in cells exposed to hydrogen peroxide is phosphorylated at both Tyr-394 and Tyr-505. in The Journal of biological chemistry 1997 (PubMed)
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Human Monoclonal LCK Primary Antibody for WB - ABIN1882258 : Koga, Caccia, Toyonaga, Spolski, Yanagi, Yoshikai, Mak: A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases. in European journal of immunology 1987 (PubMed)
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Human Monoclonal LCK Primary Antibody for FACS, IF - ABIN120650 : Brdicková, Brdicka, Angelisová, Horváth, Spicka, Hilgert, Paces, Simeoni, Kliche, Merten, Schraven, Horejsí: LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. in The Journal of experimental medicine 2003 (PubMed)
Show all 3 Pubmed References
Human Monoclonal LCK Primary Antibody for IHC - ABIN966480 : Mingjian, Wheeler, Cheng, Yonghai, Chen, Fitzwarryne, Wang: HIV/AIDS prevalence and behaviour in drug users and pregnant women in Kashgar Prefecture: case report. in Harm reduction journal 2006 (PubMed)
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Human Polyclonal LCK Primary Antibody for WB - ABIN4948306 : Bijlmakers, Marsh: Hsp90 is essential for the synthesis and subsequent membrane association, but not the maintenance, of the Src-kinase p56(lck). in Molecular biology of the cell 2000 (PubMed)
Show all 2 Pubmed References

More Antibodies against LCK Interaction Partners

Mouse (Murine) Lymphocyte-Specific Protein tyrosine Kinase (LCK) interaction partners

LCK nitration inhibits T cell activation, leading to reduced interleukin 2 (IL2 (show IL2 Antibodies)) production and proliferation.
Mutation of the basic clusters in the CD28 (show CD28 Antibodies) cytoplasmic domain reduced the recruitment to the CD28 (show CD28 Antibodies)-Lck complex of protein kinase (show CDK7 Antibodies) Ctheta; (PKCtheta (show PRKCQ Antibodies);), which serves as a key effector kinase in the CD28 (show CD28 Antibodies) signaling pathway.
A phosphosite within the SH2 Domain of Lck regulates its activation by CD45. A negative feedback loop that responds to signaling events tunes active Lck amounts and TCR sensitivity.
We show a striking 65% reduction in cellularity, preferential development of gammadelta versus alphabeta T cells, and increased expression of IL-7R in the thymus of mice expressing Cre under the proximal lck promoter (lck-cre(+) mice)
this work demonstrates a role for constitutive Lck activity in controlling antigen sensitivity
this study defines distinct and complementary requirements for proximal and distal lck promoters during T-cell development
Aurora A (show AURKA Antibodies) inhibition causes delocalized clustering of Lck at the immunological synapses and decreases its phosphorylation levels thus indicating Aurora A (show AURKA Antibodies) is required for maintaining Lck active during T-cell activation.
essential for thymic development in presence or absence of Cbl, ensuring MHC restriction of T cells
Lck-Dlx5 (show DLX5 Antibodies) mice develop T-ALLs that consistently acquire overexpression of Myc (show MYC Antibodies) and activation of Akt (show AKT1 Antibodies).
Lck-CD8 (show CD8A Antibodies) interaction is required for initial CD8 (show CD8A Antibodies) recruitment.

Human Lymphocyte-Specific Protein tyrosine Kinase (LCK) interaction partners

The ionic CD3-epsilon (show CD3E Antibodies) -Lck interaction controls the phosphorylation level of the T-cell receptor.
a previously unappreciated role for PLC-gamma1 (show PLCG1 Antibodies) in the positive regulation of Zap-70 (show ZAP70 Antibodies) and T-cell receptor tyrosine phosphorylation. Conversely, PLC-gamma1 (show PLCG1 Antibodies) negatively regulated the phosphorylation of SLP-76 (show LCP2 Antibodies)-associated proteins, including previously established Lck substrate phosphorylation sites within this complex.
autophosphorylation of the LCK active-site loop is indispensable for its catalytic activity and LCK can stimulate its own activation by adopting a more open conformation, which can be modulated by point mutations, and CD4 (show CD4 Antibodies) and CD8 (show CD8A Antibodies), T-cell coreceptors, can enhance LCK activity
the central biological role of the novel IL-2 (show IL2 Antibodies)-R/Lck/PLCgamma/PKCtheta (show PRKCQ Antibodies);/alphaPIX (show ARHGEF6 Antibodies)/Rac1 (show RAC1 Antibodies)/PYGM (show PYGM Antibodies) signalling pathway is directly related to the control of fundamental cellular processes such as T cell migration and proliferation.
Possible models of regulation of Lck by Aurora-A (show AURKA Antibodies) during T cell activation are described in the review.
Mutation of the basic clusters in the CD28 (show CD28 Antibodies) cytoplasmic domain reduced the recruitment to the CD28 (show CD28 Antibodies)-Lck complex of protein kinase (show CDK7 Antibodies) Ctheta; (PKCtheta (show PRKCQ Antibodies);), which serves as a key effector kinase in the CD28 (show CD28 Antibodies) signaling pathway.
Data suggest that T cell activation through the TCR complex is accompanied by the de novo activation of T-lymphocyte specific protein tyrosine kinase p56lck (Lck) and that phosphorylation of Tyr (show TYR Antibodies)(394) plays a role in Lck function that goes beyond inducing an open conformation of the kinase.
WASH has a pivotal role for regulation of NK cell cytotoxicity through Lck-mediated Y141 tyrosine phosphorylation.
A phosphosite within the SH2 Domain of Lck regulates its activation by CD45. A negative feedback loop that responds to signaling events tunes active Lck amounts and TCR sensitivity.
The results have revealed a novel splicing homozygous mutation of LCK that may be responsible for the clinical phenotype of HPV infection from latency to invasive carcinoma.

Pig (Porcine) Lymphocyte-Specific Protein tyrosine Kinase (LCK) interaction partners

LCK gene could be an useful candidate gene in selection for increasing litter size in pigs.

LCK Antigen Profile

Antigen Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described.

Alternative names and synonyms associated with LCK

LCK proto-oncogene, Src family tyrosine kinase (lck) antibody
LCK proto-oncogene, Src family tyrosine kinase (LCK) antibody
lymphocyte protein tyrosine kinase (Lck) antibody
LCK proto-oncogene, Src family tyrosine kinase (Lck) antibody

Hck-3 antibody
LCK antibody
Lck1 antibody
Lcktkr antibody
LSK antibody
Lskt antibody
p56 antibody
P56LCK antibody
pp58lck antibody
tkl antibody
YT16 antibody
zgc:136695 antibody

Protein level used designations for LCK

lymphocyte protein tyrosine kinase , lymphocyte-specific protein tyrosine kinase , tyrosine-protein kinase Lck-like , leukocyte C-terminal Src kinase , lymphocyte cell-specific protein-tyrosine kinase , proto-oncogene tyrosine-protein kinase LCK , T-lymphocyte specific protein tyrosine kinase p56lck , p56(LSTRA) protein-tyrosine kinase , t cell-specific protein-tyrosine kinase , tyrosine-protein kinase Lck , tyrosine protein kinase , tyrosine-protein kinase LCK , p56-LCK

GENE ID	SPECIES
414333	Danio rerio
456715	Pan troglodytes
100216439	Ovis aries
100349102	Oryctolagus cuniculus
100436326	Pongo abelii
100477981	Ailuropoda melanoleuca
16818	Mus musculus
3932	Homo sapiens
396460	Gallus gallus
313050	Rattus norvegicus
478151	Canis lupus familiaris
100233188	Sus scrofa
508890	Bos taurus

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Show all anti-Lymphocyte-Specific Protein tyrosine Kinase (LCK) Antibodies with Pubmed References