Browse our anti-LCK (LCK) Antibodies

Mouse (Murine) Lymphocyte-Specific Protein tyrosine Kinase (LCK) interaction partners

1. LCK cooperates with oncogenic FLT3-ITD in cellular transformation

2. Data show that protein tyrosine kinase p56(lck) (Lck) expression is higher in Th1 cells as compared to Th2 cells.

3. LCK nitration inhibits T cell activation, leading to reduced interleukin 2 (IL2) production and proliferation.

4. Mutation of the basic clusters in the CD28 cytoplasmic domain reduced the recruitment to the CD28-Lck complex of protein kinase Ctheta; (PKCtheta;), which serves as a key effector kinase in the CD28 signaling pathway.

5. A phosphosite within the SH2 Domain of Lck regulates its activation by CD45. A negative feedback loop that responds to signaling events tunes active Lck amounts and TCR sensitivity.

6. We show a striking 65% reduction in cellularity, preferential development of gammadelta versus alphabeta T cells, and increased expression of IL-7R in the thymus of mice expressing Cre under the proximal lck promoter (lck-cre(+) mice)

7. this work demonstrates a role for constitutive Lck activity in controlling antigen sensitivity

8. this study defines distinct and complementary requirements for proximal and distal lck promoters during T-cell development

9. Aurora A inhibition causes delocalized clustering of Lck at the immunological synapses and decreases its phosphorylation levels thus indicating Aurora A is required for maintaining Lck active during T-cell activation.

10. essential for thymic development in presence or absence of Cbl, ensuring MHC restriction of T cells

11. Lck-Dlx5 mice develop T-ALLs that consistently acquire overexpression of Myc and activation of Akt.

12. Lck-CD8 interaction is required for initial CD8 recruitment.

13. The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.

14. CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck

15. lymphoid cell kinase is the crucial effector of beta1-integrin signalling in Schwann cells

16. Study concludes that the intracellular state of Lck Study conclude that the intracellular state of Lck determines the specificity of thymic selection and that Lck association with coreceptor proteins during thymic selection is the mechanism by which MHC restriction is imposed on a randomly generated alphabetaTCR repertoire.

17. LCK could be considered a target attenuated by the anti-aging effects of CR. Integrative analysis of cDNA microarray and interactome data are powerful tools for identifying target molecules that are involved in the aging process and modulated by CR.

18. Mechanistically, poly-G oligonucleotides directly induce the phosphorylation of Lck (an essential element of the T cell-signaling pathway), thereby enhancing production of IL-2 and CD8 T cell proliferation.

19. Specific pharmacological inhibition and genetic silencing indicated the involvement of Lck in the regulation of neuritic outgrowth.

20. Data show that activation of both tuned and untuned CD4 single-positive (SP) thymocytes is Lck-dependent.

Human Lymphocyte-Specific Protein tyrosine Kinase (LCK) interaction partners

1. These findings suggest TSLP/p56lck plays an important role in allergic reactions and offers opportunities for the development of novel drugs for the treatment of AR.

2. these results provide strong evidence that mutated and overexpressed Lck is driving acute myeloid leukemia cell, CTV-1, proliferation

3. this study shows that LSK expression is a prognostic indicator in ovarian cancer and correlates with a prominent B cell transcriptional signature

4. inducible CRISPR/Cas9-targeted LCK deletion decreased YAPY357 phosphorylation and its nuclear localization. The importance of LCK in cholangiocarcinoma (CCA) biology was demonstrated by clinical observations suggesting LCK expression levels were associated with early tumor recurrence following resection of CCA

5. we show that HIV-1 infection of human T cells sequesters both Lck and Rac1 in a pericentrosomal compartment in an Nef-dependent manner.

6. Data find Lck expression and disease outcome in chronic lymphocytic leukaemia (CLL) are unrelated despite observations that its inhibition produces effects that biologically resemble the egress phenotype taken on by CLL cells treated with idelalisib.

7. Results show that Lck is highly expressed in human glioblastoma and regulates the formation of pseudopodia and the migration of human glioma cells as well as the regulation of cancer stemness.

8. Results suggest a critical role for lck kinase (Lck) as a mediator for programmed death protein 1 (PD-1) induced inhibition of t cell receptor (TCR) signaling network.

9. The results suggest that CD45RO modulates HIV-1 gp120-induced apoptosis by regulating the activity of Lymphocyte Specific Protein Tyrosine Kinase p56(lck) (Lck).

10. Intrinsic properties and plasma membrane trafficking route of lck SH4 domains sensitive to retargeting by HIV-1 Nef.

11. The ionic CD3-epsilon -Lck interaction controls the phosphorylation level of the T-cell receptor.

12. a previously unappreciated role for PLC-gamma1 in the positive regulation of Zap-70 and T-cell receptor tyrosine phosphorylation. Conversely, PLC-gamma1 negatively regulated the phosphorylation of SLP-76-associated proteins, including previously established Lck substrate phosphorylation sites within this complex.

13. autophosphorylation of the LCK active-site loop is indispensable for its catalytic activity and LCK can stimulate its own activation by adopting a more open conformation, which can be modulated by point mutations, and CD4 and CD8, T-cell coreceptors, can enhance LCK activity

14. the central biological role of the novel IL-2-R/Lck/PLCgamma/PKCtheta;/alphaPIX/Rac1/PYGM signalling pathway is directly related to the control of fundamental cellular processes such as T cell migration and proliferation.

15. Possible models of regulation of Lck by Aurora-A during T cell activation are described in the review.

16. Mutation of the basic clusters in the CD28 cytoplasmic domain reduced the recruitment to the CD28-Lck complex of protein kinase Ctheta; (PKCtheta;), which serves as a key effector kinase in the CD28 signaling pathway.

17. Data suggest that T cell activation through the TCR complex is accompanied by the de novo activation of T-lymphocyte specific protein tyrosine kinase p56lck (Lck) and that phosphorylation of Tyr(394) plays a role in Lck function that goes beyond inducing an open conformation of the kinase.

18. WASH has a pivotal role for regulation of NK cell cytotoxicity through Lck-mediated Y141 tyrosine phosphorylation.

19. A phosphosite within the SH2 Domain of Lck regulates its activation by CD45. A negative feedback loop that responds to signaling events tunes active Lck amounts and TCR sensitivity.

20. The results have revealed a novel splicing homozygous mutation of LCK that may be responsible for the clinical phenotype of HPV infection from latency to invasive carcinoma.

Pig (Porcine) Lymphocyte-Specific Protein tyrosine Kinase (LCK) interaction partners

1. LCK gene could be an useful candidate gene in selection for increasing litter size in pigs.