Mouse Complement (Lyophilized) With Diluent
Quick Overview for Mouse Complement (Lyophilized) With Diluent (ABIN925150)
Host
Lysate Type
Protein Source
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Supplier Product No.
- c201-0005
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Supplier
- Rockland
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Specificity
- The mouse complement system consists of a number of small proteins found in the blood, generally synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 25 proteins and protein fragments make up the complement system, including serum proteins, serosal proteins, and cell membrane receptors. They account for about 5% of the globulin fraction of blood serum.
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Characteristics
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Strain: Mouse - Mixed
Sex: Male -
Sterility
- Non-sterile
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Components
- Mouse Complement (Lyophilized) With Diluent
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Rat Tail
Host: Rat
Guinea Pig Spinal CordHost: Guinea Pig Normal Spinal Cord
Sheep Red Blood Cells (10% Washed Pooled Cells)H Host: Sheep Normal Red Blood Cells
Mouse BrainIEM, IHC, WB Host: Mouse Normal Brain
Chicken Red Blood Cells (10% Washed Pooled Cells)H Host: Chicken Normal Red Blood Cells
Hamster Complement (Lyophilized) With DiluentHost: Hamster Normal Complement
Guinea Pig Complement (Lyophilized) With DiluentHost: Guinea Pig Normal Complement
Rabbit Blood (In Sodium Citrate)H Host: Rabbit Normal Blood
Sheep Red Blood Cells (100% Washed Pooled Cells)H Host: Sheep Normal Red Blood Cells
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Application Notes
- pH: normal Immunoelectrophoresis: normal Hemoglobin: normal IgG Concentration: normal Immunoelectrophoresis: normal
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Comment
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The complement system helps or “complements” the ability of antibodies and phagocytic cells to clear pathogens from an organism. Complement is part of the innate immune system that is not adaptable and does not change over the course of an individual's lifetime. Complement can be recruited and brought into action by the adaptive immune system. The following are basic functions of complement: 1. Opsonisation - enhancing phagocytosis of antigens 2. Chemotaxis - attracting macrophages and neutrophils 3. Cell Lysis - rupturing membranes of foreign cells 4. Clumping of antigen-bearing agents
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitution Buffer: Restore with deionized water (or equivalent), Reconstitution Volume: 5.0 mL
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Concentration
- 82 mg/mL
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Handling Advice
- Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. COMPLEMENT IS A TEMPERATURE SENSITIVE PRODUCT. IMPROPER STORAGE WILL INACTIVATE COMPLEMENT ACTIVITY.
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Storage
- 4 °C
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Expiry Date
- 12 months
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